Development of an Exercise Program based on Gene/Protein expression and Metabolic Response during Exercise

2009 Fiscal Year Final Research Report

• Project/Area Number: 19200049
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Fukuoka University
• Principal Investigator: TANAKA Hiroaki Fukuoka University, スポーツ科学部, 教授 (00078544)
• Co-Investigator(Kenkyū-buntansha): KIYONAGA Akira 福岡大学, スポーツ科学部, 教授 (70177955) ; KUMAHARA Hideaki 福岡大学, スポーツ科学部, 助教 (40389367) ; TOBINA Takuro 福岡大学, スポーツ科学部, 研究員 (60509678) ; YAMADA Tatuo 福岡大学, 医学部, 教授 (60159217) ; ANZAI Keizo 福岡大学, 医学部, 講師 (60258556) ; YOSHIDA Hideyuki 福岡大学, 薬学部, 助教 (20301690)
• Project Period (FY): 2007 – 2009
• Keywords: メタボリックシンドローム / 肝臓内脂肪 / 骨格筋内脂肪 / 心音 / 骨格筋グリコーゲン / アディポネクチン / 前頭葉機能

Research Abstract

This study suggested that
1. The lactate threshold intensity exercise training improves insulin resistance. The reduction in ectopic lipids depends on intervention such as exercise and diet, or a combination of the two.
2. The heart sound provides valuable information for exercise prescription clinical fields.
3. Active rest with low intensity exercise prevents the decrease in exercise performance and increase muscle glycogen utilization that occurs during high-intensity intermittent exercise.
4. Adiponectin does not strongly contribute to the improvement in insulin resistance induced by exercise training.
5. The lactate threshold intensity exercise training may improve frontal lobe function.

Research Products

• [Journal Article] 運動時心弛緩時間変動の3次回帰式による年齢および体力水準による相違の比較検討 (2009)
  • Author(s): 小原繁、松田拓朗、高橋将記、Peter H. Brubaker、田中宏暁
  • Journal Title: 信学技報 109(123) Pages: 33-37
• [Journal Article] The First Heart Sound immediately after the Exercise as an Index of Exercise Stress. (2008)
  • Author(s): Matsuda Takuro, Kumahara Hideaki, Obara Shigeru, Kiyonaga Akira, Shindo Munehiro, Tanaka Hiroaki.
  • Journal Title: Int J Sport Health Sci 6 Pages: 213-218
  • Peer Reviewed
• [Journal Article] 骨格筋のPGC-1aとPDK発現を増強する運動条件からみたマラソントレーニング. (2008)
  • Author(s): 田中宏暁, 飛奈卓郎, 井上彩, 中島裕之
  • Journal Title: ランニング学研究 20 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Regulation of Skeletal Muscle Genes by Moderate-Intensity Exercise.
  • Author(s): Nishida Yuichiro, Tanaka Hiroaki, Tobina Takuro, Murakami Kiyohide, Shono Naoko, Shindo Munehiro, Ogawa Wataru, Yoshioka Mayumi, St-Amand Jonny
  • Journal Title: Int J Sport med (in press)
  • Peer Reviewed
• [Journal Article] オーディオ機器を利用した心音測定システムの開発と第一
  • Author(s): 松田拓朗、坂井洋子、平尾紀子、清永明、小原繁、田中宏暁
  • Journal Title: 心音振幅の屈曲点による運動処方の有効性健康支援 (印刷中)
  • Peer Reviewed
• [Presentation] The influence of adipocytokines, muscle and hepatic lipid content on insulin resistance in Japanese. (2009)
  • Author(s): Yoshimura Eiichi, Kumahara Hideaki, Tobina Takuro, Matono Sakiko, Kiyonaga Akira, Kimura Miyuki, Tsukikawa Hiroshi, Kawano Shinya, Etou Takashi, Irie Shin, Anzai Keizo, Tanaka Hiroaki.
  • Organizer: 20th International Diabetes Federation.
  • Place of Presentation: Montreal
  • Year and Date: 2009-10-19
• [Presentation] Change in high molecular weight adiponectin and insulin resistance after exercise and/or diet treatment. (2009)
  • Author(s): Matono Sakiko, Yoshimura Eiichi, Kumahara Hideaki, Tobina Takuro, Koshimizu Takako, Kiyonaga Akira, Anzai Keizo, Tanaka Hiroaki.
  • Organizer: 20th International Diabetes Federation.
  • Place of Presentation: Montreal
  • Year and Date: 2009-10-19
• [Presentation] 運動時心弛緩時間変動の年齢比較 (2009)
  • Author(s): 小原繁、高橋将記、松田拓朗、田中宏暁
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-19
• [Presentation] Relation between heart sound amplitude and diastolic time during exercise in persons with cardiac disease. (2009)
  • Author(s): Matsuda Takuro, Obara Shigeru, Brubaker Peter, Tanaka Hiroaki.
  • Organizer: 56th American College of Sports Medicine.
  • Place of Presentation: Seattle
  • Year and Date: 2009-05-29
• [Presentation] Comparison of cardiac diastolic time in exercise among different fitness groups. (2009)
  • Author(s): Obara Shigeru, Takahashi Masaki, Matsuda Takuro, Brubaker Peter, Tanaka Hiroaki.
  • Organizer: 56th American College of Sports Medicine.
  • Place of Presentation: Seattle
  • Year and Date: 2009-05-28
• [Presentation] 食事と運動による12週間の介入がインスリン抵抗性規定因子に及ぼす影響. (2009)
  • Author(s): 吉村英一、安西慶三、熊原秀晃、飛奈卓郎、的野早希子、小清水孝子、清永明、明比祐子、田中宏暁
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-24
• [Presentation] 過体重者に対する運動・食事制限に伴う安静代謝と除脂肪体重の変化～レプチン濃度の変化に注目して~ (2009)
  • Author(s): 井上彩、熊原秀晃、吉村英一、飛奈卓郎、桧垣靖樹、清永明、田中宏暁
  • Organizer: 第10回日本健康支援学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-02-21
• [Presentation] メタボリックシンドローム患者のインスリン抵抗性に寄与する因子の検討 (2008)
  • Author(s): 吉村英一、熊原秀晃、飛奈卓郎、的野早希子、小清水孝子、清永明、木村美由紀、月川洋、河野真也、江藤隆、入江伸、安西慶三、田中宏暁.
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分
  • Year and Date: 2008-10-18
• [Presentation] 心音屈曲点強度を用いた運動処方の有効性 (2008)
  • Author(s): 松田拓朗、坂井洋子、熊原秀晃、清永明、小原繁、田中宏暁.
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 別府
  • Year and Date: 2008-09-20
• [Presentation] Ramp式漸増運動負荷試験における心音屈曲点発現の再現性 (2008)
  • Author(s): 矢野智子、松田拓朗、坂井洋子、清永明、小原繁、田中宏暁
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 別府
  • Year and Date: 2008-09-20
• [Presentation] The automated determination of the heart sound breaking point during the ramp test. (2008)
  • Author(s): Tanaka Hiroaki, Matsuda Takuro, Sakai Yoko, Yano Satoko, Yoshimura Eiichi, Tobina Takuro, Kumahara Hideaki, Kiyonaga Akira, Shindo Munehiro.
  • Organizer: 13th European College of Sport Science.
  • Place of Presentation: Estoril
  • Year and Date: 2008-09-12
• [Presentation] βプロッカー投与が心音に及ぼす影響 (2008)
  • Author(s): 田中宏暁、松田拓朗、井上彩、小原繁
  • Organizer: 第16回日本運動生理学会
  • Place of Presentation: 奈良
  • Year and Date: 2008-08-02
• [Presentation] 第一心音振幅の屈曲点は運動耐用能の評価に有効である. (2008)
  • Author(s): 田中宏暁、松田拓朗、坂井洋子、矢野智子、吉村英一、熊原秀晃、清永明
  • Organizer: 第14回日本心臓リハビリテーション学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-07-18
• [Presentation] 食事と運動の介入による内臓脂肪減少および糖、脂質代謝改善効果. (2008)
  • Author(s): 吉村英一、安西慶三、熊原秀晃、的野早希子、飛奈卓郎、小清水孝子、清永明、田中宏暁
  • Organizer: 第16回西日本肥満研究会
  • Place of Presentation: 宮崎
  • Year and Date: 2008-07-06
• [Presentation] インスリン感受性とアディポネクチン濃度、内臓脂肪および体力の関係. (2008)
  • Author(s): 的野早希子、吉村英一、熊原秀晃、飛奈卓郎、清永明、安西慶三、田中宏暁
  • Organizer: 第16回西日本肥満研究会
  • Place of Presentation: 宮崎
  • Year and Date: 2008-07-06
• [Presentation] The heart sound breaking point is a good index of the catecholamine threshold during exercise. (2008)
  • Author(s): Matsuda Takuro, Sakai Yoko, Kumahara Hideaki, Kiyonaga Akira, Shindo Munehiro, Tanaka Hiroaki.
  • Organizer: 55th American College of Sports Medicine.
  • Place of Presentation: Indianapolis
  • Year and Date: 2008-05-30
• [Presentation] Effect of exercise and diet intervention on the anthropometric measures and metabolic risk factors in Japanese. (2008)
  • Author(s): Yoshimura Eiichi, Kumahara Hideaki, Tobina Takuro, Koshimizu Takako, Shindo Munehiro, Kiyonaga Akira, Anzai Keizo, Tanaka Hiroaki.
  • Organizer: 16th (ECO) European Congress on Obesity.
  • Place of Presentation: Leusane
  • Year and Date: 2008-05-15
• [Remarks]
  • URL: http://www.cis.fukuoka-u.ac.jp/~htanaka