2010 Fiscal Year Final Research Report
Development of novel organic phases for high selective and sensitive HPLC by controlled surface modification
| Project/Area Number |
19205011
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
IHARA Hirotaka 熊本大学, 大学院・自然科学研究科, 教授 (10151648)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAFUJI Makoto 熊本大学, 大学院・自然科学研究科, 准教授 (50332086)
SAWADA Tsuyoshi 熊本大学, 大学院・自然科学研究科, 准教授 (90240902)
NAGAOKA Shoji 熊本県産業技術センター, 材料開発部, 研究参事 (10227994)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 液体クロマトグラフィー / 分子認識 / 界面化学 / ナノ構造制御 / コア・シェル微粒子 / 分子ゲル / 超分子化学 |
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| Research Abstract |
This research project aims to develop a new class of HPLC packing materials with high selectivity. To accomplish this purpose, we proposed two goals :(1) Physical control of surface morphology and (2) chemical modification by graft polymerization on supporting materials and HPLC applications.
1. We established a new method for creation of core-shell particles with silica particles-layer shells. This method has several advantages that can be emphasized as follows :(a) the core-shell particles can be readily prepared by one-pot suspension polymerization.(b) The resultant shell is stably immobilized by covalent bonding.(c) By proper choosing the diameter and combination of silica particles, the shell structures can be adjusted from single-to multi-layers.(d) By using porous silica particles and removal of silica particles, the dimple structural surface can be created.
2. For chemical functionalization of silica surface, a polymer-grafting method has been investigated. Vinyl monomers with heterocyclic structures such as carbazole and oxazole were used. The resultant hybrids showed excellent separation ability in HPLC especially for polyaromatic hydrocarbons. It has also been established that the selectivity can be tuned by not only choosing a monomer but also polymerization method. The most successful results were observed in the base-line separation of tocopheroles containing β- and γisomers.
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Research Products
(12 results)
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[Journal Article]2010
Author(s)
H. Qiu, M. Takafuji, T. Sawada, X. Liu, S. Jiang, H. Ihara
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Journal Title
Chemical Communications
Volume: Vol.46
Pages: 8740-8742
Peer Reviewed
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[Journal Article]2010
Author(s)
A. K. Mallik, K. Shingo, U. G. Gautam, T. Sawada, M. Takafuji, H. Ihara
Volume
Vol.397
Pages
623-629
Peer Reviewed
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[Journal Article]2010
Author(s)
H. Qiu, X. Liu, S. Jiang, M. Takafuji, H. Ihara
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Journal Title
Journal of Chromatography A
Volume: Vol.1217
Pages: 5190-5196
Peer Reviewed
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[Journal Article]2009
Author(s)
H. Ihara, S. Kubota, A. Uchimura, Y. Sakai, T. Wakiya, M. M. Rahman, S. Nagaoka, M. Takafuji
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Journal Title
Materials Chemistry and Physics
Volume: Vol.114
Pages: 1-5
Peer Reviewed
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[Journal Article]2009
Author(s)
U. G. Gautam, M. P. Gautam, T. Sawada, M. Takafuji, H. Ihara
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Journal Title
Journal of Chromatography A
Volume: Vol.1216
Pages: 3571-3577
Peer Reviewed
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[Presentation] San Francisco2010
Author(s)
A. K. Mallik, T. Sawada, M. Takafuji, H. Ihara
Organizer
ACS Spring 2010 National Meeting & Exposition
Place of Presentation
San Francisco, USA
Year and Date
20100321-25
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[Presentation]2009
Author(s)
H. Ihara, S. Kubota, A. Uchimura, T. Wakiya, T. Sawada, M. Takafuji
Organizer
IUPAC 45th General Assembly & IUPAC 42nd Congress
Place of Presentation
Glasgow, UK
Year and Date
20090802-07
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