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2010 Fiscal Year Final Research Report

Implantable smart CMOS neural interface chips

Research Project

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Project/Area Number 19206042
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Electron device/Electronic equipment
Research InstitutionNara Institute of Science and Technology

Principal Investigator

OHTA Jun  Nara Institute of Science and Technology, 物質創成科学研究科, 教授 (80304161)

Co-Investigator(Kenkyū-buntansha) SHIOSAKA Sadao  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (90127233)
Co-Investigator(Renkei-kenkyūsha) TOKUDA Takashi  奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (50314539)
SASAGAWA Kiyotaka  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50392725)
NODA Toshihiko  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (20464159)
Project Period (FY) 2007 – 2010
KeywordsCMOS / 生体内埋込み / マイクロ流路 / イメージセンサ
Research Abstract

We have developed micro-fluidic device integrated with fluid output function and demonstrated its fundamental operation. The fabricated device with CMOS addressing circuits successfully demonstrates a precise output function to control 5-nl volume of liquid. In addition, we have developed an implantable device to measure fluorescence as well as potential and stimulation. These results exploit a new interface technology for neural cells and CMOS chips.

  • Research Products

    (35 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (18 results) Book (4 results) Remarks (1 results)

  • [Journal Article] CMOS Imaging Device fbr Optical Imaging of Biological Activities2011

    • Author(s)
      S.Shishido,Y.Oguro, T.Noda, K.Sasagawa, T.Tokuda, J.Ohra
    • Journal Title

      IEEJ Trans. EIS 131

      Pages: 76-82

    • Peer Reviewed
  • [Journal Article] Microfluid Ejection Device Based on Complementary Metal- Oxide-Semiconductor Technology as an Artificial Synapse2010

    • Author(s)
      K.Minakawa, T.Noda, K.Sasagawa, T.Tokuda, J.Ohta
    • Journal Title

      Jpn.J.Appl.Phys. 49

      Pages: 01AGO3-1-01AGO3-4

    • Peer Reviewed
  • [Journal Article] Multimodal Complementary Metal-Oxide-Semiconductor Sensor Device for Imaging of Fluorescence and Electrical Potential in Deep Brain of Mouse2010

    • Author(s)
      A.Tagawa, H.Minami, M.Mitani, T.Noda, K.Sasagawa, T.Tokuda, H.Tamura, Y.Hatanaka, Y.Ishikawa, S.Shiosaka, J.Ohta
    • Journal Title

      Jpn.J.Appl.Phys. 49

      Pages: 01AGO2-1-01AGO2-4

    • Peer Reviewed
  • [Journal Article] Complementary Metal Oxide Semiconductor Based Multimodal Sensor for In vivo Brain Function Imaging with a Function for Simultaneous Cell Stimulation2010

    • Author(s)
      A.Tagawa, M.Mitani, H.Minami, T.Noda, K.Sasagawa, T.Tokuda, J.Ohta
    • Journal Title

      Jpn.J.Appl.Phys. 49

      Pages: 04DLO2-1-04DLO2-4

    • Peer Reviewed
  • [Journal Article] Implantable Image Sensor with Light Guide Array Plate for Bioimaging2010

    • Author(s)
      K.Sasagawa, M.Mitani, Tetsuya Sugiyama, T.Noda, T.Tokuda, J.Ohta
    • Journal Title

      Jpn.J.Appl.Phys. 49

      Pages: 04DLO3-1-04DLO3-4

    • Peer Reviewed
  • [Journal Article] Potentiometric Dye Imaging for Pheochromocytoma and Cortical Neurons with a Novel Measurement System Using an Integrated Complementary Metal- Oxide Semiconductor Imaging Device2010

    • Author(s)
      T.Kobayashi, A.Tagawa, T.Noda, K.Sasagawa, T.Tokuda, Y.Hatanaka, H.Tamura, Y.Ishikawa, S.Shiosaka, J.Ohta
    • Journal Title

      Jpn.J.Appl.Phys. 49

      Pages: 117001-1-117001-7

    • Peer Reviewed
  • [Journal Article] Implantable CMOS biomedical devices2009

    • Author(s)
      J.Ohta, T.Tokuda, K.Sasagawa, T.Noda
    • Journal Title

      Sensors 9

      Pages: 9073-9093

    • Peer Reviewed
  • [Journal Article] Development of Complementary Metal Oxide Semiconductor Imaging Devices for Detecting Green Fluorescent Protein in the Deep Brain of a Freely Moving Mouse2009

    • Author(s)
      A.Tagawa, A.Higuchi, T.Sugiyama, K.Sasagawa, T.Tokuda, H.Tamura, Y.Hatanaka, S.Shiosaka, J.Ohta
    • Journal Title

      Jpn.J.Appl.Phys. 48

      Pages: 04C195-1-04C195-5

    • Peer Reviewed
  • [Journal Article] Micro-Chamber Device Equipped with CMOS Optical Polarization Analyzer Chip for Micro Total Analysis System2009

    • Author(s)
      K.Minakawa, H.Yamada, K.Sasagawa, T.Tokuda, J.Ohta
    • Journal Title

      Jpn.J.Appl.Phys. 48

      Pages: 04C192-1-04C192-5

    • Peer Reviewed
  • [Journal Article] An implantable and filly-integrated complementary metal- oxide semiconductor device for in vivo neural imaging and electrical interfacing with the mouse hippocampus2008

    • Author(s)
      D.C.Ng, H.Tamura, T.Mizuno, T.Tokuda, M.Nunoshita, Y.Ishikawa, S.Shiosaka, J.Ohta
    • Journal Title

      Sensors&Actuators A 145-146

      Pages: 176-186

    • Peer Reviewed
  • [Journal Article] Integrated in vivo neural imaging and interface CMOS devices : design2008

    • Author(s)
      D.C.Ng, T.Nakagawa, T.Mizuno, T.Tokuda, M.Nunoshita, H.Tamura, Y.Ishikawa, S.Shiosaka, J,Ohta
    • Journal Title

      packaging, and implementation, IEEE Sensors J 8

      Pages: 121-130

    • Peer Reviewed
  • [Journal Article] One-chip sensing device(biomedical photonic LSI)enabled to assess hippocampal steep and gradual up-regulated proteolytic activities2008

    • Author(s)
      H.Tamura, D.C.Ng, T.Tokuda, H.Naoki, T.Nakagawa, T.Mizuno, Y.Hatanaka, Y.Ishikawaa, J.Ohta, S.Shiosaka
    • Journal Title

      J.Neuroscience Methods 173

      Pages: 114-120

    • Peer Reviewed
  • [Presentation] Metallic Nano-Slit Array Lens for Spatial Resolution Improvement of In-vivo CMOS image sensor2010

    • Author(s)
      K.Sasagawa, T.Noda, T.Tokuda, M.S.Islam, J.Ohta
    • Organizer
      SSDM
    • Place of Presentation
      東京大学
    • Year and Date
      2010-09-24
  • [Presentation] Planar Multi Electrode Array Coupled CMOS Image Sensor for in vitro Electrophysiology2010

    • Author(s)
      A.Nakajima, T.Noda, K.Sasagawa, T.Tokuda, Y.Ishikawa, S.Shiosaka, J.Ohta
    • Organizer
      SSDM
    • Place of Presentation
      東京大学
    • Year and Date
      2010-09-24
  • [Presentation] Smart CMOS Image Sensors for Biomedical Applications2010

    • Author(s)
      太田淳
    • Organizer
      The 10th Emerging Information and Technology Conference (EITC-2010)
    • Place of Presentation
      Stanford, CA, USA.
    • Year and Date
      2010-08-15
  • [Presentation] Potentiometric dye imaging for pheochromocytoma and cortical neurons with a novel complementary metal-oxide semiconductor imaging sensor2010

    • Author(s)
      T.Kobayashi, A.Tagawa, T.Noda, K.Sasagawa, T.Tokuda, Y.Hatanaka, H.Tamura, Y.Ishikawa, S.Shiosaka, J.Ohta
    • Organizer
      Beyond Brain Machine Interface Workshop : From Senses to Cognition
    • Place of Presentation
      Long Beach, CA, USA.
    • Year and Date
      2010-06-20
  • [Presentation] Implantable Microelectronic Devices for Biomedical Applications2010

    • Author(s)
      太田淳
    • Organizer
      The 6th International Nanotechnology Conference on Communication and Cooperation (INC6)
    • Place of Presentation
      Grenoble, France.
    • Year and Date
      2010-05-19
  • [Presentation] Implantable CMOS Imaging Devices for Biomedical Applications2009

    • Author(s)
      J.Ohta
    • Organizer
      International Symposium on Bioelectronics and Bioinformatics
    • Place of Presentation
      Melbourne, Australia.
    • Year and Date
      2009-12-11
  • [Presentation] ACMOS sensor fbr in-vivo fiuorescence and electrical imaging in a mouse brain2009

    • Author(s)
      K.Sasagawa, A.Tagawa, H.Minami, M.Mitani, T.Noda, T.Tokuda, H.Tamura, Y.Hatanaka, Y.Ishikawa, S.Shiosaka, 太田淳
    • Organizer
      IEEE BioCAS
    • Place of Presentation
      Beijing, RPC.
    • Year and Date
      2009-11-27
  • [Presentation] A CMOS-based chemical stimulation with microfluid ejection function toward an artificial synapse2009

    • Author(s)
      K.Minagawa, T.Noda, K.Sasagawa, T.Tokuda, J.Ohta
    • Organizer
      IEEE BioCAS
    • Place of Presentation
      Beijing, RPC.
    • Year and Date
      2009-11-27
  • [Presentation] A Multimodal Sensing Device for Fluorescence Imaging and Electrical Potential Measurement of Neural Activities in a Mouse Deep Brain2009

    • Author(s)
      J.Ohta, A.Tagawa, H.Minami, T.Noda, K.Sasagawa, T.Tokuda, Y.Hatanaka, H.Tamura, S.Shiosaka
    • Organizer
      EMBCO9
    • Place of Presentation
      Minneapolis, MI.
    • Year and Date
      2009-09-06
  • [Presentation] Electrode-embedded CMOS image sensors2009

    • Author(s)
      太田淳
    • Organizer
      Int'1 Conf. Neuroprosthetic Devices
    • Place of Presentation
      National Chiao Tung Univ.,Taiwan.
    • Year and Date
      2009-03-20
  • [Presentation] Microelectronics-based devices for biomedical applications2009

    • Author(s)
      太田淳
    • Organizer
      LifeChips
    • Place of Presentation
      Univ. California, Irvine, USA.
    • Year and Date
      2009-01-09
  • [Presentation] Implantable Microelectronic Devices for Biomedical Applications2008

    • Author(s)
      太田淳
    • Organizer
      Taiwan/Japan Microelectronics International Symposium
    • Place of Presentation
      National Chiao Tung Univ., Taiwan.
    • Year and Date
      2008-12-22
  • [Presentation] An Implantable CMOS Image Sensor for Monitoring Deep Brain Activities of a Freely Moving Mouse2008

    • Author(s)
      J.Ohta, A.Higuchi, A.Tagawa, K.Sasagawa, T.Tokuda, Y.Hatanaka, H.Tamura, S.Shiosaka
    • Organizer
      IEEE BioCAS
    • Place of Presentation
      Blatimroe, MA, USA.
    • Year and Date
      2008-11-28
  • [Presentation] CMOS技術のバイオメディカル応用2007

    • Author(s)
      太田淳
    • Organizer
      システムLSIワークショップ
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2007-11-19
  • [Presentation] Development of a CMOS-based Neural Imaging and Interface Device2007

    • Author(s)
      D.C.Ng, T.Mizuno, T.Tokuda, K.Kagawa, M.Nunoshita, H.Tamura, S.Shiosaka, J.Ohta
    • Organizer
      SSDM
    • Place of Presentation
      Tukuba.
    • Year and Date
      2007-09-20
  • [Presentation] Integration of CMOS and MEMS Technologies in the Development of a Neural Imaging and Interface Device : Showcase of an Emerging Bioimaging Technique2007

    • Author(s)
      D.C Ng, T.Mizuno,T.Tokuda; M.Nunoshita, H.Tamura, Y.Ishikawa;S.Shiosaka, J.Ohta
    • Organizer
      IEEE CICC'07
    • Place of Presentation
      San Jose, CA.
    • Year and Date
      2007-09-19
  • [Presentation] Implantable CMOS sensors for biomedical applications2007

    • Author(s)
      太田淳
    • Organizer
      International Symposium on Photoeletronic Detection and Imaging(ISPDI)
    • Place of Presentation
      Beijing, RPC.
    • Year and Date
      2007-09-11
  • [Presentation] Design and Packaging of an Implantable CMOS Neural Imaging and Interface Device2007

    • Author(s)
      D.C.Ng, T.Nakagawa, T.Mizuno, T.Tokuda, M.Nunoshita,H.Tamura, Y.Ishikawa, S.Shiosaka, J.Ohta
    • Organizer
      Int'1 lmage Sensor Workshop
    • Place of Presentation
      Ogunquit, Maine.
    • Year and Date
      2007-06-07
  • [Book] CMOSイメージセンサのバイオメディカル応用概論2011

    • Author(s)
      太田淳(分担執筆)
    • Total Pages
      7
    • Publisher
      シーエムシー出版
  • [Book] Electronic Journal別冊2008イメージセンサ&カメラモジュール(分担執筆)(第2編第4章イメージセンサのバイオ・医療分野への応用)2008

    • Author(s)
      太田淳(分担執筆)
    • Total Pages
      4
    • Publisher
      電子ジャーナル
  • [Book] CMOSイメージセンサの最新動向-高性能化,高機能化から応用展開まで-2007

    • Author(s)
      太田淳監修
    • Total Pages
      281
    • Publisher
      シーエムシー出版
  • [Book] 第7章ビジョンチップ,(金光義彦,深津晋著)(シリコンフォトニクス)2007

    • Author(s)
      太田淳(分担執筆)
    • Total Pages
      35
    • Publisher
      オーム社
  • [Remarks] ホームページ等

    • URL

      http://mswebs.naist.jp/CABs/pdslab/

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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