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2010 Fiscal Year Final Research Report

Development of Micro Fluidic Systems for Real Time Function Analysis of Single Biomolecules

Research Project

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Project/Area Number 19206046
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionWaseda University

Principal Investigator

SHOJI Shuichi  Waseda University, 理工学術院, 教授 (00171017)

Co-Investigator(Renkei-kenkyūsha) 関口 哲志  早稲田大学, ナノテクノロジー研究所, 准教授 (70424819)
水野 潤  早稲田大学, ナノテクノロジー研究所, 准教授 (60386737)
Project Period (FY) 2007 – 2010
Keywords計測システム / 微細プロセス技術 / バイオデバイス
Research Abstract

Micro fluidic Systems for real time function analysis of single biomolecules were proposed and demonstrated. By applying MEMS and μTAS technologies, functional particular cell trapping and culture micro flow systems, a damage free cell rapture device, high through-put bio molecules sorting systems and high performance biomolecules analysis chips have been developed. Multi sample treatment and handling system technologies are also proposed and demonstrated.

  • Research Products

    (46 results)

All 2011 2010 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (31 results) Book (5 results)

  • [Journal Article] High-Throughput Single-Cell Manipulation System for a Large Number of Target Cells2011

    • Author(s)
      T.Arakawa, M.Noguchi, K.Sumitomo, Y.Yamaguchi, S.Shoji
    • Journal Title

      Biomicrofluidics Vol.5 No.1

      Pages: 014114

    • Peer Reviewed
  • [Journal Article] Improvement of Filtration Performance Using Self-Turning of Flow Resistance2011

    • Author(s)
      D.H.Yoon, Y.K.Bahk, B.H.Kwon, S.S.Kim, Y.-D.Kim, T.Arakawa, J.S.Go, S.Shoji
    • Journal Title

      Japanese Journal of Applied Physics 50

      Pages: 017201

    • Peer Reviewed
  • [Journal Article] Microfluidic Cell Sorter with Flow Switching Triggered by a Sol-Gel Transition of a Thermo-Reversible Gelation Polymer2010

    • Author(s)
      K.Ozaki, H.Sugino, Y.Shirasaki, T.Aoki, T.Arakawa, T.Funatsu, S.Shoji
    • Journal Title

      Sensors and Actuators B 150

      Pages: 449-455

    • Peer Reviewed
  • [Journal Article] Integration in a Multilayer Microfluidic Chip of 8 Parallel Cell Sorters with Flow Control by Sol-Gel Transition of Thermoreversible Gelation Polymer2010

    • Author(s)
      H.Sugino, T.Arakawa, Y.Nara, Y.Shirasaki, K.Ozaki, S.Shoji, T.Funatsu
    • Journal Title

      Lab on a Chip 2010,10

      Pages: 2559-2565

    • Peer Reviewed
  • [Journal Article] On-Chip Microfluidic Sorting with Fluorescence Spectrum Detection and Multiway Separation2009

    • Author(s)
      H Sugino, K.Ozaki, Y.Shirasaki, T.Arakawa, S.Shoji, T.Funatsu
    • Journal Title

      Lab on a Chip 2009

      Pages: 1254-1260

    • Peer Reviewed
  • [Journal Article] Fabrication of Post-Hydrophilic Treatment-Free Plastic Biochip Using Polyurea Film2009

    • Author(s)
      H.Shinohara, Y.Takahashi, J.Mizuno, S.Shoji
    • Journal Title

      Sensors & Actuators A Vol.154

      Pages: 187-191

    • Peer Reviewed
  • [Journal Article] Polymer Microchip Integrated with Nano-Electrospray Tip for Electrophoresis-Mass Spectrometry2008

    • Author(s)
      H.Shinohara, T.Suzuki, F.Kitagawa, J.Mizuno, K.Otsuka, S.Shoji
    • Journal Title

      Sensors and Actuators B 132

      Pages: 368-373

    • Peer Reviewed
  • [Journal Article] Parallel and Passive Distribution to Arrayed Microwells Using Self-Regulating Pinched Flow2008

    • Author(s)
      K.Kawai, M.Kanai, T.Munaka, H.Abe, A.Murakami, S.Shoji
    • Journal Title

      Sensors and Materials Vol.20, No.6

      Pages: 281-288

    • Peer Reviewed
  • [Journal Article] Micro-Bubble Formation with Organic Membrane in a Multiphase Microfluidic System2008

    • Author(s)
      T.Arakawa, T.Yamamoto, S.Shoji
    • Journal Title

      Sensors & Actuators A Vol.143

      Pages: 58-63

    • Peer Reviewed
  • [Journal Article] Rapid Multi-Reagents Exchange TIRFM Microfluidic System for Single Biomolecular Imaging2007

    • Author(s)
      T.Arakawa, T.Sameshima, Y.Sato, T.Ueno, Y.Shirasaki, T.Funatsu, S.Shoji
    • Journal Title

      Sensors and Actuators B 128

      Pages: 218-225

    • Peer Reviewed
  • [Presentation] Volume Controlled High Throughput Picoliter Droplet Generation System Using Cascade Multi-Stage Separation Channel2011

    • Author(s)
      M.Fujii, K.Kawai, D.H.Yoon, S.Shoji
    • Organizer
      The 24th International Conference on Micro Electro Mechanical Systems : MEMS 2011(1201-1204)
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      2011-01-24
  • [Presentation] High Speed Generation of Uniform Femtoliter Volume Droplets Using Cascade Multi-Stage Separation Microfluidic Device2010

    • Author(s)
      M.Fujii, K.Kawai, D.H.Yoon, S.Shoji
    • Organizer
      23rd International Microproccesses and Nanotechnology Conference : MNC2010(11C-4-2)
    • Place of Presentation
      Fukuoka
    • Year and Date
      20101109-20101111
  • [Presentation] MEMS/ナノテクノロジーによるマイクロ/ナノ流体システム構築とバイオ・医療への応用2010

    • Author(s)
      庄子習一
    • Organizer
      第60回日本アレルギー学会秋季学術大会(Vol.59 No.9・10 1157)
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
  • [Presentation] Partly Disposable Lab-on-a-Chip System Using Electromagnetically-Drive Hydraulic Valves2010

    • Author(s)
      K.Miyamoto, K.Kawai, S.Shoji
    • Organizer
      23rd International Microproccesses and Nanotechnology Conference : MNC2010(12D-11-123)
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-11-12
  • [Presentation] Fabrication of Vertical and High-Aspect-Ratio Glass Microfluidic Device by Borosilicate Glass Molding to Silicon Structure2010

    • Author(s)
      K.Kawai, F.Yamaguchi, A.Nakahara, S.Shoji
    • Organizer
      The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010(1193-1195)
    • Place of Presentation
      Groningen, The Netherlands
    • Year and Date
      2010-10-05
  • [Presentation] Size Controllable Polymeric Microlens Fabrication by Using a Multiphase Droplet Including Air Core2010

    • Author(s)
      D.H.Yoon, T.Arakawa, J.S.Go, S.Shoji
    • Organizer
      The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010(1118-1120)
    • Place of Presentation
      Groningen, The Netherlands
    • Year and Date
      2010-10-05
  • [Presentation] Selective Droplet Sampling Flow System Using Minimum Number of Horizontal Pneumatic Valves Formed by Single Step PDMS Molding2010

    • Author(s)
      D.H.Yoon, D.Wakui, T.Sekiguchi, S.Shoji
    • Organizer
      The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010(1085-1087)
    • Place of Presentation
      Groningen, The Netherlands
    • Year and Date
      2010-10-05
  • [Presentation] On-Chip Gas Concentration Gradient Formation Using Poreflon^<TM> and Neoflon^<TM> for In Vitro Observation of Cancer Cell2010

    • Author(s)
      Y.Harada, K.Kawai, S.Shoji
    • Organizer
      The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2010(551-553)
    • Place of Presentation
      Groningen, The Netherlands
    • Year and Date
      2010-10-04
  • [Presentation] Fabrication of High-Aspect-Ratio Amorphous Perfluorinated Polymer Structure for Total Internal Reflection Fluorescence Microscopy2010

    • Author(s)
      A.Nakahara, Y.Shirasaki, K.Kawai, O.Ohara, J.Mizuno, S.Shoji
    • Organizer
      The 36th International Conference on Micro & Nano Engineering : MNE 2010(P-LIFE-68)
    • Place of Presentation
      Genoa, Italy
    • Year and Date
      2010-09-21
  • [Presentation] MEMS Fabricated Liquid Chromatography Microchip for Practical Uses2010

    • Author(s)
      M.Noguchi, M.Tsunoda, J.Mizuno, T.Funatsu, S.Shoji
    • Organizer
      The 23rd IEEE International Conference on Micro Electro Mechanical Systems : MEMS 2010(911-914)
    • Place of Presentation
      Hong Kong
    • Year and Date
      2010-01-27
  • [Presentation] Multi Channel Droplet Sorting Device with Horizontal Pneumatic Actuation Using Single Layer PDMS Flexible Parallel Walls2010

    • Author(s)
      D.Wakui, S.Takahashi, T.Sekiguchi, S.Shoji
    • Organizer
      The 23rd IEEE International Conference on Micro Electro Mechanical Systems : MEMS 2010(144-147)
    • Place of Presentation
      Hong Kong
    • Year and Date
      2010-01-26
  • [Presentation] High Performance Multiple E. Coli Cell Sorting System Using Thermosensitive Hydrogel and Fluorescence Spectrum Detection2009

    • Author(s)
      K.Ozaki, H.Sugino, T.Arakawa, Y.Shirasaki, T.Funatsu, S.Shoji
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1856-1858)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-04
  • [Presentation] Microvalve Integrated All Neoflon Accurate Sample Injecter Fabricated by Low Temperature Embossing and Bonding2009

    • Author(s)
      K.Miyamoto, K.Kawai, T.Sato, M.Kanai, S.Shoji
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1590-1592)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-04
  • [Presentation] Precise Volume Controlled Multi Reagents Injective Microwell Array for Efficient Cell Function Analysis2009

    • Author(s)
      Y.Shibata, K.Kawai, M.Kanai, 庄子習一
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1488-1490)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-04
  • [Presentation] Generation of Polystyrene Microcapsules as Nanoliter Volume Gas Encapsulants by Using Gas-Organic-Water Multiphase Junction2009

    • Author(s)
      D.H.Yoon, T.Arakawa, J.S.Go, S.Shoji
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1422-1424)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-04
  • [Presentation] Multi Uniform Picoliter Volume Droplets Generation and Sorting Device for Digital Picoliter Dispenser2009

    • Author(s)
      M.Fujii, K.Kawai, S.Shoji
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μ TAS 2009(1356-1358)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-11-04
  • [Presentation] MEMS Based Cell Function Analysis Micro Fluidic Devices and Systems2009

    • Author(s)
      庄子習一
    • Organizer
      The 3rd IEEE International Conference on Nano/Molecular Medicine and Engineering : IEEE-NANOMED 2009(16)
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2009-10-20
  • [Presentation] 100 Picoliter Droplet Handling Using 256 (2^8) Microvalve Array with 18 Multiplexed Control Lines2009

    • Author(s)
      K.Kawai, Y.Shibata, S.Shoji
    • Organizer
      The 15th International Conference on Solid-State Sensors, Actuators and Microsystems : Transducers 2009(802-805)
    • Place of Presentation
      Denver
    • Year and Date
      2009-06-23
  • [Presentation] Large Scale Micro Fluidic Systems for Sequential Trapping, Labeling and Content Extraction of Single Cells2009

    • Author(s)
      M.Noguchi, T.Arakawa, Y.Yamaguchi, S.Shoji
    • Organizer
      The 15th International Conference on Solid-State Sensors, Actuators and Microsystems : Transducers 2009(628-631)
    • Place of Presentation
      Denver, USA
    • Year and Date
      2009-06-22
  • [Presentation] MEMS Based Cell Function Analysis Micro Fluidic Systems2009

    • Author(s)
      S.Shoji, K.Kawai, H.Shinohara, D.H.Yoon, T.Arakawa, T.Funatsu
    • Organizer
      The 11th Korean MEMS Conference : KMEMS 2009(1-3)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2009-04-03
  • [Presentation] Precise Titration Microfluidic System Using Sub-Picoliter Droplet Injection2009

    • Author(s)
      K.Kawai, M.Fujii, S.Shoji
    • Organizer
      22nd IEEE International Conference on Micro Electro Mechanical Systems : MEMS 2009(519-522)
    • Place of Presentation
      Sorrento, Italy
    • Year and Date
      2009-01-27
  • [Presentation] Cell Function Analysis Tools Fabricated by MEMS and Nanotechnology2008

    • Author(s)
      S.Shoji, T.Arakawa, K.Kawai, T.Funatsu
    • Organizer
      International Symposium on Surface Science and Nanotechnology : ISSS-5(407)
    • Place of Presentation
      Tokyo
    • Year and Date
      20081109-20081113
  • [Presentation] High Performance Microfluidic Device for Sequential Trapping, Labeling and Content Extraction of Single Cells2008

    • Author(s)
      Y.Murakami, T.Arakawa, S.Nomura, Y.Yamaguchi, S.Shoji
    • Organizer
      The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(1774-1776)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20081012-20081016
  • [Presentation] Multiplexed Pneumatic Valve Control System for Large Scale Integrated Microfluidic Circuit (LSIMC)2008

    • Author(s)
      K.Kawai, Y.Shibata, M.Kanai, S.Shoji
    • Organizer
      The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(683-685)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20081012-20081016
  • [Presentation] High Performance Multiple Biomolecules Sorting System2008

    • Author(s)
      K.Ozaki, H.Sugino, T.Arakawa, Y.Shirasaki, T.Funatsu, S.Shoji
    • Organizer
      The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(489-491)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20081012-20081016
  • [Presentation] Dynamic Imaging of Single Biomolecular Interaction Using Flow Control and TIRFM2008

    • Author(s)
      T.Arakawa, T.Sameshima, Y.Sato, Y.Sumiyoshi, T.Ueno, Y.Shirasaki, T.Funatsu, S.Shoji
    • Organizer
      The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(296-298)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20081012-20081016
  • [Presentation] Cell Rupture Microfluidic Device Using Nano Needle Allay for Damage-Free Extraction of Organelles2008

    • Author(s)
      T.Arakawa, Y.Shirasaki, D.Yamazaki, T.Funatsu, S.Shoji
    • Organizer
      The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS2008(215-217)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20081012-20081016
  • [Presentation] Post-Hydrophilic Treatment Free Plastic Biochip Fabrication Method Using Polyurea Film2008

    • Author(s)
      H.Shinohara, Y.Takahashi, J.Mizuno, S.Shoji
    • Organizer
      21st IEEE International Conference on Micro Electro Mechanical Systems : IEEE MEMS 2008(367-370)
    • Place of Presentation
      Tucson
    • Year and Date
      20080113-20080117
  • [Presentation] MEMS/NTを応用した細胞機能解析マイクロシステム2008

    • Author(s)
      庄子習一、荒川貴博、川合健太郎、篠原秀敏、船津高志
    • Organizer
      第17回日本コンピュータ外科学会大会(213-214)
    • Place of Presentation
      東京女子医科大学、東京
    • Year and Date
      2008-11-01
  • [Presentation] High Speed Organelles Sorting Microsystem Driven by a Single Pressure Source2007

    • Author(s)
      T.Aoki, Y.Shirasaki, T.Arakawa, H.Sugino, T.Funatsu, S.Shoji
    • Organizer
      The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2007(224-226)
    • Place of Presentation
      Paris
    • Year and Date
      20071007-20071011
  • [Presentation] Efficient Addressable Fluid Control System Using Pneumatic Valve Array2007

    • Author(s)
      K.Kawai, M.Kanai, S.Shoji
    • Organizer
      The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences : μTAS 2007(32-34)
    • Place of Presentation
      Paris
    • Year and Date
      20071007-20071011
  • [Book] BIO INDUSTRY(第27巻 第3号)2010

    • Author(s)
      庄子習一、川合健太郎
    • Total Pages
      7(22-28)
    • Publisher
      (株)シーエムシー出版
  • [Book] MEMS/NEMS工学全集(Fundamentals and Applications of MEMS/NEMS Engineering)2009

    • Author(s)
      庄子習一
    • Total Pages
      8(727-734)
    • Publisher
      (株)テクノシステム
  • [Book] マイクロ・ナノ化学チップと医療・環境・バイオ分析2009

    • Author(s)
      庄子習一
    • Total Pages
      9(16-24)
    • Publisher
      技術教育出版社
  • [Book] バイオテクノロジーシリーズ細胞分離・操作技術の最前線2008

    • Author(s)
      庄子習一、荒川貴博、川合健太郎
    • Total Pages
      9
    • Publisher
      シーエムシー出版
  • [Book] M41 Micropump : liquid2007

    • Author(s)
      S.Shoji, H.Sato, R.Zengerle
    • Publisher
      Comprehensive Microsystems, Elsevier Science Ltd.

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Published: 2012-01-26   Modified: 2016-04-21  

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