2010 Fiscal Year Final Research Report
Epigenetic control of repetitive sequences in plant genome
| Project/Area Number |
19207002
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
KAKUTANI Tetsuji National Institute of Genetics, 総合遺伝研究系, 教授 (20332174)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ゲノム構築 / 機能 / 再編 / 発現 / 維持 |
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| Research Abstract |
Genomes of vertebrates contain large proportion of repetitive sequences. The repetitive sequences are potential threat to genome stability and controlled by epigenetic modifications, such as DNA methylation. In this project, we examined epigenetic controls of repetitive sequences using a flowering plant Arabidopsis. Through forward genetic approaches, we identified a jmjC-domain-containing protein IBM1, which controls methylation in genes in negative manner (Saze et al 2008 Science). Genome-wide methylation profiling of the ibm1 mutant revealed that IBM1 protein is necessary for excluding DNA methylation from transcribed genes (Miura et al 2009 EMBO J). We also showed that a retrotransposon sequence is critical for imprinted expression of FWA gene (Fujimoto et al 2008 PLoS Genet). In addition, by combination of genetics and genomics, we identified diverse families of mobile endogenous transposons in the Arabidopsis genome (Tsykahara et al 2009 Nature).
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[Presentation] Genetics of DNAmethylation in genes and transposons in Arabidopsis2009
Author(s)
Kakutani T., Saze H,, Miura A., Inagaki S,, Kobayashi A,, Nakamura M,, Tsukahara S,, Fu Y.
Organizer
第32回分子生物学会年会シンポジウムEmerging power of epigenomics in life science
Place of Presentation
横浜
Year and Date
2009-12-10
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