2010 Fiscal Year Final Research Report
Measurements and analysis of fluctuations in cellular systems
| Project/Area Number |
19207012
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SAKO Yasushi The Institute of Physical and Chemical Research, 佐甲細胞情報研究室, 主任研究員 (20215700)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 1分子計測 / 顕微計測 / ノイズ / 細胞内情報処理 / 細胞分化 / 細胞増殖 |
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| Research Abstract |
Fluctuations of biological reactions were measured and analyzed for dynamics of proteins, reactions of molecular systems, and cell behaviors in the EGF-Ras-MAPK system, which is a cell signaling network. Intramolecular dynamics and translational movements of EGF receptor and RAF ; reaction dynamics between EGF receptor and Grb2, Ras and RAF, and MAPKK and MAPK ; and fluctuations of cell fate decision that occurred spontaneously and in response to EGF and NGF have been studied.
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