2009 Fiscal Year Final Research Report
Analysis of factors implicated in pathogenicity of mononegaviruses and development of a vaccine candidate.
| Project/Area Number |
19208025
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAI Chieko The University of Tokyo, 医科学研究所, 教授 (10167330)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Hiroyuki 東京大学, 農学生命科学研究科, 教授 (40155891)
YONEDA Misako 東京大学, 医科学研究所, 准教授 (40361620)
SATOU Hiroki 東京大学, 医科学研究所, 助教 (50418654)
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| Project Period (FY) |
2007 – 2009
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| Keywords | モノネガウイルス / モービリウイルス / 病原性 / 組換えウイルス / 宿主因子 |
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| Research Abstract |
We investigated the key factors in pathogenicity of morbilliviruses, and developed a vaccine for Nipah virus infection. For morbilliviruses, it was discovered that MV induced different cellular responses in a cell-type specific mannar, and viral nucleocapsid protein had inhibitory potency for IFN-α/β and γ signaling. For Nipah virus, we showed that accessory proteins play key roles in it's pathogenicity. We have also showed that our established recombinant measles virus expressing Nipah virus protein effectively protected hamsters from NiV infection.
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[Journal Article] Phosphorylation of measles virus nucleoprotein upregulates the transcriptional activity of minigenomic RNA.2008
Author(s)
Hagiwara K., Sato H., Inoue Y., Watanabe A., Yoneda M., Ikeda F., Fujita K., Fukuda H., Takamura C., Kozuka-Hata H., Oyama M., Sugano S., Ohmi S., Kai C.
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Journal Title
Proteomics 8
Pages: 1871-1879
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[Journal Article] A novel monolayer cell line derived from human umbilical cord blood cells shows high sensitivity to measles virus.2007
Author(s)
Kobune F., Ami Y., Katayama M., Takahashi M., Tuul R., Korukluoglu G., Kiyohara T., Miura R., Sato H., Yoneda M., Kai C.
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Journal Title
J.Gen.Virol. 88
Pages: 1565-1567
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