2010 Fiscal Year Final Research Report
The investigation of molecular mechanisms underlying refractory respiratory diseases and exploration of novel therapeutic targets
| Project/Area Number |
19209031
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAGASE Takahide The University of Tokyo, 医学部附属病院, 教授 (40208004)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Takao 東京大学, 大学院・医学系研究科, 教授 (80127092)
KUHIHARA Hiroki 東京大学, 大学院・医学系研究科, 教授 (20221947)
ISHI Satoshi 秋田大学, 大学院・医学系研究科, 教授 (10300815)
TAKAI Daiya 東京大学, 医学部附属病院, 講師 (90361493)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 |
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| Research Abstract |
In respiratory diseases, there are several inflammatory disorders such as COPD, ARDS and pulmonary fibrosis, to which no pharmaceutical agents are currently effective. However, their mechanisms still remain to be elucidated. The purpose of this project is to investigate the roles of lipid mediators and TAZ in these disorders using genetically-engineered mice. We found that lipid mediators and TAZ were involved in the pathogenesis of inflammatory lung disorders. Our results suggest that these mediators might provide a novel therapeutic approach to these diseases.
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[Journal Article] Identification of GOS2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches.2010
Author(s)
Kusakabe M, Kutomi T, Watanabe K, Emoto N, Aki N, Kage H, Hamano E, Kitagawa H, Nagase T, Sano A, Yoshida Y, Fukami T, Murakawa T, Nakajima J, Takamoto S, Ota S, Fukayama M, Yatomi Y, Ohishi N, Takai D
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Journal Title
Int J Cancer 15 : 126
Pages: 1895-1902
Peer Reviewed
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[Journal Article] Renaltubular dysmorphogenesis leading to multicystic formation and lung emphysema in mice lacking TAZ.2008
Author(s)
Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, Mitani A, Nagase T, Yatomi Y, Aburatani H, Nakagawa O, Cobo-Stark P, Igarashi P, Murakami M, Tominaga J, Sato T, Asano T, Kurihara Y, Kurihara H
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Journal Title
Am J Physiol 294
Pages: F542-553
Peer Reviewed
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[Journal Article] Beta-defensin overexpression induces progressive muscle degeneration in mice.2007
Author(s)
Yamaguchi Y, Nagase T, Tomita T, Nakamura K, Fukuhara S, Amano T, Yamamoto H, Ide Y, Suzuki M, Teramoto S, Asano T, Kangawa K, Nakagata N, Ouchi Y, Kurihara H
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Journal Title
Am J Physiol Cell Physiol 292
Pages: C2141-2149
Peer Reviewed
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[Journal Article] A second-generation profiling system for quantitative methylation analysis of multiple gene promoters : application to lung cancer.2007
Author(s)
Sano A, Kage H, Sugimoto K, Kitagawa H, Aki N, Goto A, Fukuyama M, Nakajima J, Takamoto S, Nagase T, Yatomi Y, Ohishi N, Takai D
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Journal Title
Oncogene 26
Pages: 6518-6525
Peer Reviewed
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