2009 Fiscal Year Final Research Report
Optic-spinal multiple sclerosis : clarification of pathogenesis, establishment of new disease entity and treatment
| Project/Area Number |
19209032
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
ITOYAMA Yasuto Tohoku University, 大学院・医学系研究科, 教授 (30136428)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIHARA Kazuo 東北大学, 大学院・医学系研究科, 教授 (70280873)
NAKASHIMA Ichiro 東北大学, 病院, 助教 (50333810)
MISU Tatsuro 東北大学, 大学院・医学系研究科, 助教 (00396491)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 多発性硬化症 / 脱髄疾患 / 視神経脊髄炎 / 脳神経疾患 |
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| Research Abstract |
Optic-spinal multiple sclerosis (OSMS) is an intractable neurologic disease characterized by recurrent severe optic neuritis and transverse myelitis, and is essentially identical to neuromyelitis optica (NMO). Based on the discovery of aquaporin 4 (AQP4) antibody, an OSMS/NMO-specific autoantibody, the present study clarified its clinical features including longitudinally extended myelitis (>3 vertebral segments), established pathogenicity of AQP4 antibody and the new clinical entity as astrocytopathy, and proved therapeutic efficacy of plasma exchange and immunosuppression in the disease.
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[Journal Article] Neuromyelitis optica : pathogenicity of patient immunoglobulin in vivo2009
Author(s)
Bradl M, Misu T, Takahashi T, Watanabe M, Mader S, Reindl M, Adzemovic M, Bauer J, Berger T, Fujihara K, Itoyama Y, Lassmann H.
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Journal Title
Ann Neurol 66
Pages: 630:643
Peer Reviewed
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[Journal Article] Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO : a study on antibody titer2007
Author(s)
Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M, Watanabe S, Shiga Y, Kanaoka C, Fujimori J, Sato S, Itoyama Y.
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Journal Title
Brain 130
Pages: 1235-1243
Peer Reviewed
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