2009 Fiscal Year Final Research Report
Identification of a receptor for an anorexigenic molecule, Nesfatin-1, and its signal transduction systems
| Project/Area Number |
19209035
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Gunma University |
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Principal Investigator |
MOR Masatomo Gunma University, 大学院・医学系研究科, 教授 (80174382)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Hiroyuki 群馬大学, 大学院・医学系研究科, 講師 (20251100)
YAMADA Masanobu 群馬大学, 大学院・医学系研究科, 講師 (90261833)
OKADA Shuichi 群馬大学, 大学院・医学系研究科, 講師 (20260474)
HASHIMOTO Kohshi 群馬大学, 大学院・医学系研究科, 講師 (30396642)
INOUE Kinji 埼玉大学, 理学部, 教授 (50091963)
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| Project Period (FY) |
2007 – 2009
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| Keywords | Nesfatin / 食欲調節 / 受容体 / 視床下部 / ノックアウトマウス |
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| Research Abstract |
We identified a novel receptor, G-protein coupled receptor-nesfatin (GPCRn), specific to Nesfatin-1, which is an anorexigenic molecule expressed in both the hypothalamus and peripheral tissues, including gastric and duodenal mucosa and pancreas. As expected, the hypothalamic extracts from mice deficient in the GPCRn showed a loss of specific binding of Nesfatin-1, but this specific binding was not observed in the Hella cells expressing the GPCRn. These results suggest that GPCRn may form a heterodimer with another receptors or receptor-like partners. Nesfartin-1-induced signal transduction included the pathway of Oxytocin neurons in the paraventricular nucleus and the activation of POMC and CART expression in the nucleus tract solitarius. Theses findings indicate that Nesfatin-1 is considerably involved in the regulation of obese development at the central and peripheral levels.
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[Journal Article] Tat-bidning protein-1 (TBP-1), an ATPase of 19s regulatory particles of the 26s proteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop22009
Author(s)
Satoh T, Ishizuka T, Tomaru T, Yoshino S, Nakajima Y, Hashimoto K, Shibusawa N, Monden T, Yamada M, Mori M.
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Journal Title
Endocrinology 150
Pages: 3283-3290
Peer Reviewed
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[Journal Article] Peripheral administration of nesfatin-1 reduces food intake in mice : The leptin-independent mechanism2009
Author(s)
Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M.
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Journal Title
Endocrinology 150
Pages: 662-671
Peer Reviewed
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[Journal Article] Nesfatin-1-regulated paraventricular oxytocinergic signaling causes anorexia through a leptin-independent melanocortin pathway2009
Author(s)
Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, Oh-I S, Hashimoto K, Shimizu H, Nakata M, Mori M, Yada T.
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Journal Title
Cell Metabolism 10
Pages: 355-65
Peer Reviewed
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[Journal Article] CDK5-dependent phosphorylation of the Rho family GTPase TC10 alpha regulates insulin-stimulated GLUT4 translocation2008
Author(s)
Okada S, Yamada E, Saito T, Ohshima K, Hashimoto K, Yamada M, Uehara Y, Tsuchiya T, Shimizu H, Tatei K, Isumi Y, Yamauchi K, Hisanaga SI, Pessin JE, Mori M.
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Journal Title
J Biol Chem 283
Pages: 35455-63
Peer Reviewed
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