2008 Fiscal Year Final Research Report
Research for development of novel therapeutic approaches targeting molecules regulating invasion and drug resistance of malignant gliomas
| Project/Area Number |
19209048
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
SAYA Hideyuki Keio University, 医学部, 教授 (80264282)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 細胞・組織 / 脳腫瘍 / シグナル伝達 / 癌 / 低分子化合物 |
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| Research Abstract |
悪性グリオーマの強い浸潤能と治療抵抗性を規定する分子シグナルを明らかにし、それらに基づく新たな治療戦略の基礎を構築することを目的として研究を行った。具体的には : (1) 悪性グリオーマの浸潤能は細胞外マトリクスの産生能と極めて強い相関を示すので、マトリクスの産生を評価するアッセイ系を確立し、そのアッセイを用いて浸潤能を抑制できる低分子化合物の候補を取得した。(2) 抗がん剤効果が細胞分裂期での停止時間と相関することを見出し、その概念を用いて抗がん剤の効果を判定するシステムを構築した。(3) ヒトグリオブラストーマおよびPNETに類似した組織型を持つマウス脳腫瘍モデルを構築した。
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Research Products
(31 results)
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[Journal Article] K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells2009
Author(s)
Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, Akinaga S, Murakata C, Honda S, Nitta M, Saya H and Yamashita Y
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Journal Title
Cancer Res 69
Pages: 3901-3909
Peer Reviewed
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[Journal Article] NF1 tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein,collapsin response mediator protein-22008
Author(s)
Patrakitkomjorn S, Kobayashi D, Morikawa T, Wilson MM, Tsubota N, Irie A, Ozawa T, Aoki M, Arimura N, Kaibuchi K, Saya H and Araki N
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Journal Title
J Biol Chem 283
Pages: 9399-9413
Peer Reviewed
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[Journal Article] HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint2008
Author(s)
Kim S, Park SY, Yong H, Famulski JK, Chae S, Lee JH, Kang CM, Saya H, Chan GK, and Cho H
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Journal Title
Oncogene 27
Pages: 3457-3464
Peer Reviewed
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[Journal Article] Visualizing the dynamics of p21^<Waf1/Cip1> cyclin-dependent kinase inhibitor expression in living animals2007
Author(s)
Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu T, Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuki N and Hara E
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Journal Title
Proc Natl Acad Sci USA 104
Pages: 15034-15039
Peer Reviewed
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[Journal Article] Wynshaw-Boris A and Hirotsune S. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation,separation, and TACC3 recruitment2007
Author(s)
Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya H, Toyoshima YY, Kinoshita K
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Journal Title
Mol Cell Biol 27
Pages: 352-367
Peer Reviewed
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