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2009 Fiscal Year Final Research Report

molecular analyses and translational research of neuroblastoma based upon a clinical trial of the nation-wide group study

Research Project

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Project/Area Number 19209054
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

KANEKO Michio  University of Tsukuba, 大学院・人間総合科学研究科, 教授 (60152807)

Co-Investigator(Kenkyū-buntansha) HAYASHI Yutaka  東北大学, 医学部, 教授 (40125638)
IEHARA Tomoko  京都府立医科大学, 大学院・医学研究科, 講師 (20285266)
MUGISHIMA Hideo  日本大学, 医学部, 教授 (80183648)
HIYAMA Eizo  広島大学, 自然科学研究支援開発センター, 教授 (00218744)
TAJIRI Tatsuro  九州大学, 大学院・医学研究院, 准教授 (80304806)
KIKUTA Atsushi  福島県立医科大学, 医学部, 講師 (40224894)
HISHIKI Tomoro  千葉大学, 医学部附属病院, 講師 (00375776)
FUKUZAWA Masahiro  大阪大学, 大学院・医学研究科, 教授 (60165272)
KUMAGAI Masaaki  国立成育医療センター, 血液科, 医長 (60170049)
HAYASHI Yasuhide  群馬県衛生環境研究所, 群馬県立小児医療センター, 研究員 (30238133)
OHIRA Miki  千葉県がんセンター(研究所), 臨床ゲノムセンター, 室長 (20311384)
NAKAGAWA Atsuko  国立成育医療センター(研究所), 臨床検査部, 医長 (90227736)
FUKUSHIMA Takashi  筑波大学, 大学院・人間総合科学研究科, 講師 (30323299)
Project Period (FY) 2007 – 2009
Keywords小児腫瘍学 / 神経芽腫
Research Abstract

There registered 61 cases with high risk neuroblastoma, on a clinical trial protocol of Japan Neuroblastoma Study Group (JNBSG). The cohort is now under clinical observation after a protocol therapy. Each biopsy sample at initial diagnosis was analysed by array-CGH, gene expression array, and amplification/mutation of a gene for example ALK. Much scientific information will be revealed after collecting the clinical out come of the cohort.

  • Research Products

    (8 results)

All 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results) Book (1 results)

  • [Journal Article] ヒト神経芽腫および横紋筋肉腫移植ヌードマウス腫瘍に対するCPT-11の抗腫瘍効果2010

    • Author(s)
      金子節子, 金子道夫
    • Journal Title

      小児がん 47(1)

      Pages: 98-104

    • Peer Reviewed
  • [Journal Article] Prolonged Low-dose Administration of the Cyclooxygenase-2 Inhibitor Celecoxib Enhances the Antitumor Activity of Irinotecan against Neuroblastoma Xenografts2009

    • Author(s)
      Kaneko M, Kaneko S, Suzuki K
    • Journal Title

      Cancer Science 100(11)

      Pages: 2193-2201

    • Peer Reviewed
  • [Journal Article] 小児外科疾患術後患者の長期予後-成人期における諸問題-2009

    • Author(s)
      金子道夫
    • Journal Title

      7. 小児悪性固形腫瘍、日本外科学会誌 110(4)

      Pages: 203-206

    • Peer Reviewed
  • [Journal Article] The Inter national Neuroblastoma Risk Group (INRG) classification system : an INRG Task Force report2009

    • Author(s)
      Cohn SL, Iehara T, et al.
    • Journal Title

      J Clin Oncol 27(2)

      Pages: 289-297

    • Peer Reviewed
  • [Presentation] COX-2阻害剤 celecoxib はヒト神経芽腫移植ヌードマウス腫瘍に対するCPT-11の抗腫瘍効果を増強する2009

    • Author(s)
      金子節子, 鈴木健之, 金子道夫
    • Organizer
      第46回日本小児外科学会
    • Place of Presentation
      大阪
    • Year and Date
      20090601-20090603
  • [Presentation] Risks and benefits of ending of mass screening for neuroblastoma at 6 months of age in Japan2009

    • Author(s)
      Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Matsuzaki A, Hara T, Taguchi T
    • Organizer
      42nd Annual Meeting Pacific Association of Pediatric Surgeons
    • Place of Presentation
      香港
    • Year and Date
      20090510-20090514
  • [Presentation] Telomere biology in neuroblastoma : Focusing on telomere binding proteins and alternative strengthening of telomere2009

    • Author(s)
      Hiyama E
    • Organizer
      42nd Annual Meeting of Pacific Association of Pediatric Surgeons
    • Place of Presentation
      香港
    • Year and Date
      2009-05-13
  • [Book] Transworld Research Network2009

    • Author(s)
      Hiyama E, et al.
    • Total Pages
      220
    • Publisher
      Clinical Application of Molecular Diagnosis

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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