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2009 Fiscal Year Final Research Report

Regenerative response to insults : a novel strategy based on endothelial regeneration

Research Project

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Project/Area Number 19209055
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionOsaka University

Principal Investigator

OGURA Hiroshi  Osaka University, 医学系研究科, 講師 (70301265)

Co-Investigator(Kenkyū-buntansha) SUGIMOTO Hisashi  大阪大学, 名誉教授 (90127241)
KUWAGATA Yasuyuki  大阪大学, 医学系研究科, 准教授 (50273678)
MATSUMOTO Naoya  大阪大学, 医学部附属病院, 助教 (50359808)
Project Period (FY) 2007 – 2009
Keywords侵襲 / 再生 / 血管内皮 / 骨髄間質細胞 / 移植 / 前駆細胞 / 治療 / 多臓器障害
Research Abstract

The objectives of this study were to evaluate the regenerative response of endothelium in patients with systemic inflammatory response syndrome and to examine the effects of mesenchymal stem cells in a rat model with multiple organ dysfunction syndrome (MODS). In patients with sepsis, long-term endothelial activation was observed with increased endothelial progenitor cells in blood and enhanced VEGF receptors on these cells. Transplantation of mesenchymal stem cells inhibit the production of inflammatory cytokines, protect against endothelial damage and improve survival in a rat model with MODS. Transplantation of mesenchymal stem cells may be a novel strategy to attenuate MODS.

  • Research Products

    (4 results)

All 2010 2009 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] The effect of antithrombin on pulmonary endothelial damage induced by crush injury.2009

    • Author(s)
      Sonoi H, 松本直也, 小倉裕司, Hosotsubo H, Noguchi K, Kuwagata Y, 杉本壽, ら
    • Journal Title

      Shock Vol32

      Pages: 593-600

    • Peer Reviewed
  • [Journal Article] Sepsis患者における血管内皮前駆細胞の動向2007

    • Author(s)
      松嶋麻子、小倉裕司、康泰珍、松本直也、鍬方安行、田中裕、嶋津岳士、杉本壽, ら
    • Journal Title

      shock誌 Vol22

      Pages: 100-105

    • Peer Reviewed
  • [Presentation] ラット敗血症・多臓器不全モデルにおける骨髄間質細胞移植による抗炎症効果の評価2010

    • Author(s)
      松本直也, ら
    • Organizer
      第38回日本救急医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09
  • [Presentation] 急性期DIC病態2009

    • Author(s)
      小倉裕司, ら
    • Organizer
      第37回日本救急医学会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-10-30

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Published: 2012-01-26   Modified: 2016-04-21  

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