2009 Fiscal Year Final Research Report
Creation of Cementum Inducing peptide for functional Implant
| Project/Area Number |
19209061
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
INOUE Takashi Tokyo Dental College, 歯学部, 教授 (20125008)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBA Kiyotaka 癌研究所, 蛋白創製研究部, 部長 (40196415)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHINARI Masao 東京歯科大学, 歯学部, 教授 (10085839)
MATSUZAKA Kenichi 東京歯科大学, 歯学部, 准教授 (70266568)
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| Project Period (FY) |
2007 – 2009
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| Keywords | インプラント / チタン / 人工ペプチド / チタン結合ペプチド / セメント質 / RGDモチーフ / 融合タンパク / 細胞接着 |
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| Research Abstract |
The purpose of this study was to create the cementum inducing peptide for functional implant which have a cementum with sharpy's fibers just same manner as natural tooth. We produced the artificial protein with Titanium-binding protein (TBP-1) which bind to the titanium, and RGD motif which connected to the integrin of the cells using Molclaft. We published these in vitro results on the Biomacromolecules (2008). From these results suggest that we could bind the various kinds of protein on the titanium surface on the titanium surface by TBP-1. In the near future, we could make a functional implant which have a periodontal ligament-like structure. In the mean time, Zirconium have given attention to implant materials instead of titanium, we investigate Zirconium binding protein as well as TBP.
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