Analysis of virulence factors of cariogenic bacteria for cardiovascular diseases

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19209063
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Osaka University
• Principal Investigator: OOSHIMA Takashi Osaka University, 大学院・歯学研究科, 教授 (80116003)
• Project Period (FY): 2007 – 2010
• Keywords: う蝕 / 全身疾患 / 循環器疾患

Research Abstract

(1)心臓血管外科手術時に摘出された検体と同患者からのデンタルプラーク検体における口腔細菌の存在の分析
(2)In vitro実験系における口腔細菌の心臓血管系への病原性の解析
(3)動物モデルにおける口腔細菌の心臓血管系への病原性の解析
(4)心臓血管疾患に対する高リスク菌種・菌株保有者の簡易同定法の確立
(5)S.mutans血清型k型株のゲノム解析

Research Products

• [Journal Article] Molecular characterization of Streptococcus mutans clinical strains with gene encoding collagen-binding adhesin (2010)
  • Author(s): Nakano K, Nomura R, Taniguchi N, Lapirattanakul J, Kojima A, Naka S, Senawongse P, Srisatjaluk R, Gronroos L, Alaluusua S, Matsumoto M, Ooshima T.
  • Journal Title: Arch Oral Biol 55 Pages: 34-38
  • Peer Reviewed
• [Journal Article] Serotype classification of Streptococcus mutans and its detection outside the oral cavity (2009)
  • Author(s): Nakano K, Ooshima T.
  • Journal Title: Future Microbiol 4 Pages: 891-902
  • Peer Reviewed
• [Journal Article] Detection of oral bacteria in cardiovascular specimens (2009)
  • Author(s): Nakano K, Nemoto H, Nomura R, Inaba H, Yoshioka H, Taniguchi K, Amano A, Ooshima T.
  • Journal Title: Oral Microbiof Immunol 24 Pages: 64-68
  • Peer Reviewed
• [Journal Article] Protein antigen in serotype k Streptococcus mutans clinical isolates (2008)
  • Author(s): Nakano K, Nomura R, Nemoto H, Lapirattanakul J, Taniguchi N, Gronroos L, Alaluusua S, Ooshima T.
  • Journal Title: J Dent Res 87 Pages: 964-968
  • Peer Reviewed
• [Journal Article] Streptococcus mutans exhibits clonal variation as revealed by multilocus sequence typing (2007)
  • Author(s): Nakano K, Lapirattanakul J, Nomura R, Nemoto H, Alaluusua S, Gronroos L, Vaara M, Hamada S, Ooshima T, Nakagawa I.
  • Journal Title: J Clin Microbiol 45 Pages: 2616-2625
  • Peer Reviewed
• [Presentation] Genes concerning adhesion to extracellular matrix in Streptococcus mutans from Thai subjects (2009)
  • Author(s): Lapirattanakul J, Nakano K, Senawongse P, Leelataweewud P, Srisatjaluk R, Ooshima T.
  • Organizer: 5th International Dental Collaboration of the Mekong River Region Congress
  • Place of Presentation: Hanoi, Vietnam
  • Year and Date: 2009-10-14
• [Presentation] Molecular analyses of Streptococcus mutans strains with collagen-binding properties (2009)
  • Author(s): Nomura R, Nakano K, Taniguchi N, Kojima A, Naka S, Ooshima T.
  • Organizer: 56th ORCA congress
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2009-07-01
• [Presentation] Serotype k strains of Streptococcus mutans are potential risk factor to cause cerebral hemorrhage (2009)
  • Author(s): Nakano K, Taniguchi N, Kojima A, Nomura R, Wada K, Ooshima T.
  • Organizer: 56th ORCA congress
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2009-07-01
• [Presentation] Clinical analysis of gene encoding collagen-binding adhesin of Streptococcus mutans (2008)
  • Author(s): Nomura R, Nakano K, Taniguchi N, Lapirattanakul J, Nemoto H, Ooshima T.
  • Organizer: 86th Conference of International Association of Dental Research
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-03
• [Presentation] Characterization of surface protein antigen in serotype k Streptococcus mutans clinical isolates (2007)
  • Author(s): Nakano K, Nomura R, Nemoto H, Ooshima T.
  • Organizer: 54th ORCA Congress
  • Place of Presentation: Helsingor, Denmark
  • Year and Date: 2007-07-04
• [Book] Oral bacteria detected in the hearts of patients with valvular diseases In : Bennington EH editor. Horizons in World Cardiovascular Research (2010)
  • Author(s): Nakano K, Taniguchi K, Ooshima T.
  • Publisher: Nova Science Publishers(in press)