2010 Fiscal Year Final Research Report
Analysis of virulence factors in cariogenic bacteria for cardiovascular diseases
| Project/Area Number |
19209063
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
OOSHIMA Takashi Osaka University, 大学院・歯学研究科, 教授 (80116003)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Kazuhiko 大阪大学, 歯学部附属病院, 講師 (00379083)
NOMURA Ryota 大阪大学, 大学院・歯学研究科, 助教 (90437385)
NAKAGAWA Ichiro 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (70294113)
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| Project Period (FY) |
2007 – 2010
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| Keywords | Streptococcus mutans / う蝕 / 全身疾患 / 循環器疾患 / コラーゲン結合タンパク / 循環器疾患 / 血清型 |
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| Research Abstract |
Streptococcus mutans is known to be a major cariogenic bacterial species that may also show virulence in blood. Serotype k strains, a minor serotype present in the oral cavity, may show higher levels of virulence in blood, because of a longer duration of bacteremia due to lower antigenicity derived from defects of major cell surface antigens. In addition, the higher rate of the organisms with collagen-binding properties identified in this strain may also be associated with virulence toward blood vessel endothelia with exposed internal collagen tissue.
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[Journal Article] Molecular characterization of Streptococcus mutans clinical strains with gene encoding collagen-binding adhesin.2010
Author(s)
Nakano K, Nomura R, Taniguchi N, Lapirattanakul J, Kojima A, Naka S, Senawongse P, Srisatjaluk R, Gronroos L, Alaluusua S, Matsumoto M, Ooshima T
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Journal Title
Arch Oral Biol 55
Pages: 34-39
Peer Reviewed
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[Journal Article] Detection of novel serotype k Streptococcus mutans in infective endocarditis patients.2007
Author(s)
Nakano K, Nomura R, Nemoto H, Mukai T, Yoshioka H, Shudo Y, Hata H, Toda K, Taniguchi K, Amano A, Ooshima T
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Journal Title
J Med Microbiol 56
Pages: 1413-1415
Peer Reviewed
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[Journal Article] Serotype distribution of Streptococcus mutans, a pathogen of dental caries, in cardiovascular specimens from Japanese patients.2007
Author(s)
Nakano K, Nemoto H, Nomura R, Homma H, Yoshioka H, Shudo Y, Hata H, Toda K, Taniguchi K, Amano A, Ooshima T
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Journal Title
J Med Microbiol 56
Pages: 551-556
Peer Reviewed
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