2009 Fiscal Year Final Research Report
Analyses of synapse formation and elimination, the cellular bases of long-term memory, with special attention to their apparent symmetry
| Project/Area Number |
19300108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Osaka University |
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Principal Investigator |
OGURA Akihiko Osaka University, 大学院・生命機能研究科, 教授 (30260631)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 分子・細胞神経科学 / 長期可塑性 |
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| Research Abstract |
The purpose of this study is to analyze the mechanisms underlying long-lasting synaptic plasticity, the presumed cellular basis of long-term memory, by using the recipient's original system (stable cultures of brain slice). The long-lasting synaptic enhancement coupled with synapse formation and the long-lasting synaptic suppression coupled with synapse elimination are symmetric phenomena in many properties. Taking this symmetry as a clue for solution, the analyses reveal that the enhancement and suppression are mediated by brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF), respectively. The mechanisms are symmetric indeed.
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Research Products
(11 results)
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[Journal Article] Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival2009
Author(s)
Koshimizu H, Kiyosue K, Hara T, Hazama S, Suzuki S, Uegaki K, Nagappan G, Zaitsev E, Hirokawa T, Tatsu Y, Ogura A, Lu B, Kojima M
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Journal Title
Molecular Brain 2:#27(on line publication)
Peer Reviewed
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