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2009 Fiscal Year Final Research Report

Analyses of synapse formation and elimination, the cellular bases of long-term memory, with special attention to their apparent symmetry

Research Project

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Project/Area Number 19300108
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionOsaka University

Principal Investigator

OGURA Akihiko  Osaka University, 大学院・生命機能研究科, 教授 (30260631)

Project Period (FY) 2007 – 2009
Keywords分子・細胞神経科学 / 長期可塑性
Research Abstract

The purpose of this study is to analyze the mechanisms underlying long-lasting synaptic plasticity, the presumed cellular basis of long-term memory, by using the recipient's original system (stable cultures of brain slice). The long-lasting synaptic enhancement coupled with synapse formation and the long-lasting synaptic suppression coupled with synapse elimination are symmetric phenomena in many properties. Taking this symmetry as a clue for solution, the analyses reveal that the enhancement and suppression are mediated by brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF), respectively. The mechanisms are symmetric indeed.

  • Research Products

    (11 results)

All 2010 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Book (3 results)

  • [Journal Article] Analysis of gene expression changes associated with long-lasting synaptic enhancement in hippocampal slice cultures after repetitive exposures to glutamate2010

    • Author(s)
      Kawaai K, Tominaga-Yoshino K, Urakubo T, Taniguchi N, Kondoh Y, Tashiro H, Ogura A, Tashiro T
    • Journal Title

      J Neurosci Res (in press)

    • Peer Reviewed
  • [Journal Article] Distinct signaling pathways of presursor BDNF and mature BDNF in cultured cerebellar granule neurons2010

    • Author(s)
      Koshimizu H, Hazama S, Hara T, Ogura A, Kojima M
    • Journal Title

      Neurosci Lett (in press)

    • Peer Reviewed
  • [Journal Article] Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival2009

    • Author(s)
      Koshimizu H, Kiyosue K, Hara T, Hazama S, Suzuki S, Uegaki K, Nagappan G, Zaitsev E, Hirokawa T, Tatsu Y, Ogura A, Lu B, Kojima M
    • Journal Title

      Molecular Brain 2:#27(on line publication)

    • Peer Reviewed
  • [Journal Article] Repetitive induction of late-phase LTP produces long-lasting synaptic enhancement accompanied by synaptogenesis in cultured hippocampal slices2008

    • Author(s)
      Tominaga-Yoshino K, Urakubo T, Okada M, Matsuda H, Ogura A
    • Journal Title

      Hippocampus 18

      Pages: 281-293

    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor (BDNF) stimulates cholesterol biosynthesis and accumulates presynaptic proteins in lipid rafts: A novel role for BDNF in synapse development2007

    • Author(s)
      Suzuki S, Kiyosue K, Hazama S, Ogura A, Kashihara M, Hara T, Koshimizu H, Kojima M
    • Journal Title

      J Neurosci 27

      Pages: 6417-6427

    • Peer Reviewed
  • [Journal Article] Postsynaptic GABA receptor signalling enhances LTD in mouse cerebellar Punkinje cells2007

    • Author(s)
      Kamikubo Y, Tabata T, Kakizawa S, Kawakami D, Watanabe M, Ogura A, Iino M, Kano M
    • Journal Title

      J Physiol Lond 585

      Pages: 549-563

    • Peer Reviewed
  • [Presentation] Is memory transfer reproducible in vitro? A long-lasting synaptic enhancement after repeated LTP induction in cultured brain slice2009

    • Author(s)
      Iijima K, Oe Y, Tominaga-Yoshino K, Ogura A
    • Organizer
      36th Intntl Congr Physiol Sci
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
  • [Presentation] Possible involvement of proBDNF-p75NTR signals in LTD-repetition operated synaptic suppression, a form of long-lasting synaptic plasticity2009

    • Author(s)
      Egashira Y, Kojima M, Tominaga-Yoshino K, Ogura A
    • Organizer
      36th Intntl Congr Physiol Sci
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
  • [Book] 神経伝達物質受容体イオンチャネル2007

    • Author(s)
      小倉明彦
    • Total Pages
      272-275
    • Publisher
      朝倉書店
  • [Book]

    • Author(s)
      http://www. fbs. osaka-u. ac. jp/jp/labo/18/
  • [Book]

    • Author(s)
      http://www. bio. sci. osaka-u. ac. jp/bio_web/ lab_page/ogura/home. html

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Published: 2011-06-18   Modified: 2016-04-21  

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