2010 Fiscal Year Final Research Report
Pathology of the Alzheimer disease : prevention of cerebral β-amyloid deposition
| Project/Area Number |
19300122
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Gunma University |
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Principal Investigator |
YAMAGUCHI Haruyasu Gunma University, 医学部, 教授 (00158114)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Takashi 埼玉医科大学, 医学部, 准教授 (60239605)
SASAKI Atsushi 埼玉医科大学, 医学部, 教授 (80225862)
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| Project Period (FY) |
2007 – 2010
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| Keywords | Alzheimer病 / βアミロイド / 認知症 / ポリフェノール |
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| Research Abstract |
The purpose of the study is to find polyphenol, which reduce cerebral β-amyloid deposition, a causative factor of the Alzheimer disease. We administrated tannic acid to transgenic mice which develop cerebral β-amyloid deposition, and examined neuropathologically and behavior-physiologically. We found that tannic acid reduce cerebral β-amyloid deposition and also reduce mental deficit. Moreover, we demonstrated new findings as follows : accumulation of protofibril at synaptic area ; influence of ganglioside on amyloid angiopathy ; and β-amyloid deposition in tamarin.
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[Journal Article] Intraneuronal amyloid Beta accumulation and oxidative damage to nucleic acids in Alzheimer disease.2010
Author(s)
Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Shimohama S, Lee HG, Zhu X, Smith MA, Perry G
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Journal Title
Neurobiol Dis. 37(3)
Pages: 731-737
Peer Reviewed
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[Journal Article] Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage.2007
Author(s)
Nikolic WV, Bai Y, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle RD, Giunta B, Morgan D, Town T, Tan J
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Journal Title
Proc Natl Acad Sci U S A. 104(7)
Pages: 2507-12
Peer Reviewed
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