2009 Fiscal Year Final Research Report
Clinicopathological study of risk factors for degenerative dementia : the Hisayama Study
| Project/Area Number |
19300125
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyushu University |
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Principal Investigator |
IWAKI Toru Kyushu University, 大学院・医学研究院, 教授 (40221098)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Satoshi 九州大学, 大学院・医学研究院, 准教授 (90294917)
SASAKI Kensuke 九州大学, 大学院・医学研究院, 助教 (80380616)
KIYOHARA Yutaka 九州大学, 大学院・医学研究院, 教授 (80161602)
TANIZAKI Yumihiro 九州大学, 大学院・医学研究院, 学術研究員 (30437785)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 認知症 / アルツハイマー病 / 老人斑 / 神経原線維変化 / 糖尿病 / インスリン / 耐糖能異常 / 生活習慣病 |
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| Research Abstract |
We examined the association between diabetes-related factors and pathology of Alzheimer's disease in the Hisayama study. The results suggest that hyperinsulinemia and hyperglycemia caused by insulin resistance accelerate neuritic plaque formation in combination with the effects of APOE ε4. There were no relationships between diabetes-related factors and neurofibrillary tangles.
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Research Products
(19 results)
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[Journal Article] Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama Study.2009
Author(s)
Matsui Y, Tanizaki Y, Arima H, Yonemoto K, Doi Y, Ninomiya T, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y
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Journal Title
J Neurol Neurosurg Psychiatry. 80(4)
Pages: 366-370
Peer Reviewed
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[Journal Article] Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: The Hisayama study.2008
Author(s)
Fujimi K, Sasaki K, Noda K, Wakisaka Y, Tanizaki Y, Matsui Y, Sekita A, Iida M, Kiyohara Y, Kanba S, Iwaki T
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Journal Title
Brain Pathol. 18(3)
Pages: 317-325
Peer Reviewed
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[Journal Article] Insulin resistance is associated with the pathology of Alzheimer' s disease: the Hisayama Study.
Author(s)
Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matui Y, Sekita A, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T
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Journal Title
Peer Reviewed
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