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2009 Fiscal Year Final Research Report

Clinicopathological study of risk factors for degenerative dementia : the Hisayama Study

Research Project

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Project/Area Number 19300125
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyushu University

Principal Investigator

IWAKI Toru  Kyushu University, 大学院・医学研究院, 教授 (40221098)

Co-Investigator(Kenkyū-buntansha) SUZUKI Satoshi  九州大学, 大学院・医学研究院, 准教授 (90294917)
SASAKI Kensuke  九州大学, 大学院・医学研究院, 助教 (80380616)
KIYOHARA Yutaka  九州大学, 大学院・医学研究院, 教授 (80161602)
TANIZAKI Yumihiro  九州大学, 大学院・医学研究院, 学術研究員 (30437785)
Project Period (FY) 2007 – 2009
Keywords認知症 / アルツハイマー病 / 老人斑 / 神経原線維変化 / 糖尿病 / インスリン / 耐糖能異常 / 生活習慣病
Research Abstract

We examined the association between diabetes-related factors and pathology of Alzheimer's disease in the Hisayama study. The results suggest that hyperinsulinemia and hyperglycemia caused by insulin resistance accelerate neuritic plaque formation in combination with the effects of APOE ε4. There were no relationships between diabetes-related factors and neurofibrillary tangles.

  • Research Products

    (19 results)

All 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (13 results)

  • [Journal Article] Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama Study.2009

    • Author(s)
      Matsui Y, Tanizaki Y, Arima H, Yonemoto K, Doi Y, Ninomiya T, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y
    • Journal Title

      J Neurol Neurosurg Psychiatry. 80(4)

      Pages: 366-370

    • Peer Reviewed
  • [Journal Article] Development of oligomeric prion-protein aggregates in a mouse model of prion disease.2009

    • Author(s)
      Sasaki K, Minaki H, Iwaki T
    • Journal Title

      J. Pathol. 219(1)

      Pages: 123-130

    • Peer Reviewed
  • [Journal Article] Prion protein oligomers in Creutzfeldt-Jakob disease detected by gel-filtration centrifuge columns.2009

    • Author(s)
      Minaki H, Sasaki K, Honda H, Iwaki T
    • Journal Title

      Neuropathology 29(5)

      Pages: 536-542

    • Peer Reviewed
  • [Journal Article] Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: The Hisayama study.2008

    • Author(s)
      Fujimi K, Sasaki K, Noda K, Wakisaka Y, Tanizaki Y, Matsui Y, Sekita A, Iida M, Kiyohara Y, Kanba S, Iwaki T
    • Journal Title

      Brain Pathol. 18(3)

      Pages: 317-325

    • Peer Reviewed
  • [Journal Article] Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama study2007

    • Author(s)
      Fujimi K, Noda K, Sasaki K, Wakisaka Y, Tanizaki Y, Iida M, Kiyohara Y, Kanba S, Iwaki T
    • Journal Title

      Dement Geriatr Cogn Disord. 23

      Pages: 423-431

    • Peer Reviewed
  • [Journal Article] Insulin resistance is associated with the pathology of Alzheimer' s disease: the Hisayama Study.

    • Author(s)
      Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matui Y, Sekita A, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T
    • Journal Title

      Neurology (in press)

    • Peer Reviewed
  • [Presentation] 耐糖能異常とアルツハイマー病の病理学的関連2009

    • Author(s)
      松崎尊信
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-06
  • [Presentation] プリオン持続感染細胞株におけるプリオン蛋白重合度の解析2009

    • Author(s)
      柴野智子
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-06
  • [Presentation] ペントサンポリ硫酸治療症例におけるプリオン蛋白重合度変化の解析2009

    • Author(s)
      本田裕之
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-06
  • [Presentation] 臨床所見で中枢性低換気を合併した家族性パーキンソン症状を示し、病理学的にTDP-43陰性のタウオパチーを認めた46歳女性剖検例2009

    • Author(s)
      尾本雅俊
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-06
  • [Presentation] 多彩なプリオン蛋白沈着パターンを示したMM1+2孤発性クロイツフェルト・ヤコブ病の一剖検例2009

    • Author(s)
      佐々木健介
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-06
  • [Presentation] (6)本田裕之、プリオン病の病理形態学的および蛋白生化学的定量解析の試み2008

    • Author(s)
      本田裕之
    • Organizer
      第49回日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      20080500
  • [Presentation] プリオン蛋白オリゴマーの簡便な検出法2008

    • Author(s)
      皆木晴彦
    • Organizer
      第49回日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      20080500
  • [Presentation] プリオン病モデルマウスおける重合プリオン蛋白形成の経時的解析2008

    • Author(s)
      佐々木健介
    • Organizer
      第49回日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      20080500
  • [Presentation] 耐糖能異常とアルツハイマー病の病理学的関連2008

    • Author(s)
      松崎尊信
    • Organizer
      第49回日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      20080500
  • [Presentation] Clinicopathological study of dementia: the Hisayama study2007

    • Author(s)
      Iwaki T
    • Organizer
      The 4th International Symposium. Kyushu University COE Program. Frontier Research and Education on Lifestyle-Related Diseases based on the Large-scale Cohort Study
    • Place of Presentation
      福岡
    • Year and Date
      20071100
  • [Presentation] Time course of the development of PrP aggregates in a mouse model of prion disease2007

    • Author(s)
      Sasaki K
    • Organizer
      Prion 2007
    • Place of Presentation
      英国エジンバラ
    • Year and Date
      20070900
  • [Presentation] 高齢者における耐糖能異常と高血圧が認知症発症に及ぼす影響2007

    • Author(s)
      谷崎弓裕
    • Organizer
      第49回日本老年医学会
    • Place of Presentation
      札幌
    • Year and Date
      20070600
  • [Presentation] 一般住民におけるレビー小体型認知症の新しい診断基準に基づく臨床病理学的検討2007

    • Author(s)
      藤見恒平
    • Organizer
      第48回日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      20070500

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Published: 2011-06-18   Modified: 2016-04-21  

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