Dynamic function analysis of skin sympathetic nerve using optical coherence tomography and its application to clinical diagnoses

2008 Fiscal Year Final Research Report

• Project/Area Number: 19300159
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University
• Principal Investigator: HARUNA Masamitsu Osaka University, 大学院・医学系研究科, 教授 (20029333)
• Co-Investigator(Kenkyū-buntansha): YAMATODANI Yamatodani 大阪大学, 大学院・医学系研究科, 教授 (30116123) ; OHMI Masato 大阪大学, 大学院・医学系研究科, 助教 (60273645)
• Co-Investigator(Renkei-kenkyūsha): TAMADA Yasuhiko 愛知医科大学, 医学部, 教授 (30115597)
• Project Period (FY): 2007 – 2008
• Keywords: 生体情報・計測

Research Abstract

交感神経の支配下で機能する汗腺や末梢血管は重要な微小器官であり、そのダイナミックな生理機能を解明することが重要である。本研究では、光コヒーレンストモグラフィ(OCT)を用いて、ヒト指汗腺や小動脈の生理機能を可視化した。汗腺においては、外部刺激に反応する精神性発汗の動的解析を行い、新たに内部発汗を見出した。小動脈においては、脈動を観測し、弾性型動脈と筋型動脈として同時に機能することを明らかにした。

Research Products

• [Journal Article] Dynamic analysis of internal and external mental sweating by optical coherence tomography (2009)
  • Author(s): M. Ohmi, M. Tanigawa, A. Yamada, Y. Ueda, and M. Haruna
  • Journal Title: J. Biomed. Opt vol.14 Pages: 014026-1-7
  • Peer Reviewed
• [Journal Article] Dynamic analysis of laser ablation of biological tissue using a real-time OCT (2009)
  • Author(s): M. Ohnishi, D. Takada, M. Ohmi, and M. Haruna
  • Journal Title: Biomedical Optics Symposium (BiOS2009), Proc. SPIE vol.7175 Pages: 7175-39-1-5
• [Journal Article] Maximum- intensity-projection imaging for dynamic analysis of mental sweating by optical coherence tomography (2009)
  • Author(s): H. Saigusa, Y. Ueda, M. Ohmi, M. Ohnishi, M. Kuwabara, and M. Haruna
  • Journal Title: Biomedical Optics Symposium (BiOS2009), Proc. SPIE vol.7168 Pages: 7168-84-1-5
  • Peer Reviewed
• [Journal Article] Maximum-intensity- projection imaging for dynamic analysis of mental sweating by optical coherence tomography (2008)
  • Author(s): H. Saigusa, Y. Ueda, A. Yamada, M. Ohmi, M. Ohnishi, M. Kuwabara, and M. Haruna
  • Journal Title: Appl. Phys. Express(APEX) vol.1, 098001 Pages: 098001-1-3
  • Peer Reviewed
• [Journal Article] Dynamic optical coherence tomography of small arteries and veins of human fingers (2008)
  • Author(s): M. Kuwabara, T. Fuji, M. Ohmi, and M. Haruna
  • Journal Title: Appl. Phys. Express (APEX) vol.1, 058001 Pages: 058001-1-3
  • Peer Reviewed
• [Journal Article] Maximum-intensity- projection images for dynamic analysis of mental sweating by optical coherence tomography (2008)
  • Author(s): H. Saigusa, Y. Ueda, A. Yamada, M. Ohmi, and M. Haruna
  • Journal Title: 19-th Int'1 Conf. Optical Fiber Sensors (OFS-19), Proc. SPIE vol.7004 Pages: 70040V-1-1-5
  • Peer Reviewed
• [Journal Article] Dynamic analysis of eccrin sweat glands on human fingertips by optical coherence tomography (2008)
  • Author(s): M. Haruna, M. Ohmi, Y. Ueda, A. Yamada and H. Saigusa
  • Journal Title: Biomedical Optics Symposium (BiOS2008), Proc. SPIE vol.6847 Pages: 684770-1-5
• [Journal Article] Kuwabara, "Dynamic OCT for physiological functions of micro organs in human fingers" (2007)
  • Author(s): M. Haruna, M. Ohmi, Y. Ueda, T. Fuji, A. Yamada, H. Saigusa, and M.
  • Journal Title: Photonics Asia, Conf. in Health Care and Biomedical Optics, Proc. SPIE vol.6826 Pages: 682603-1-6
• [Journal Article] 光コヒーレンストモグラフィを用いたヒト指汗腺の動態観察 (2007)
  • Author(s): 上田悦弘、近江雅人、春名正光
  • Journal Title: 発汗学 vol.14, no.1 Pages: 2-6
• [Presentation] Maximum-intensity- projection imaging for dynamic analysis of mental sweating by optical coherence tomography (2009)
  • Author(s): H. Saigusa, et.al.
  • Organizer: SPIE Biomedical Optics Symposium(BiOS2009)
  • Place of Presentation: San Jose CA, USA, Jan
  • Year and Date: 20090000
• [Presentation] 光コヒーレンストモグラフィ(OCT)-原理と応用- (2009)
  • Author(s): 春名正光
  • Organizer: 第42回光波センシング技術研究会
  • Place of Presentation: 埼玉大学
  • Year and Date: 2009-12-09
• [Presentation] OCTによる精神性内部発汗のダイナミック解析 (2009)
  • Author(s): 谷川基務
  • Organizer: レーザー学会第29回年次大会
  • Place of Presentation: 徳島大学た
  • Year and Date: 2009-01-11
• [Presentation] Dynamic optical coherence tomography of eccrin sweat glands and peripheral vessels (2008)
  • Author(s): M. Haruna, et.al.
  • Organizer: Int'l Conf. Laser Appl. in Life Sciences (LALS 2008)
  • Place of Presentation: Taipei Int'l Convention Center, Taiwan
  • Year and Date: 20081204-06
• [Presentation] Dynamic optical coherence tomography for skin physiology (2008)
  • Author(s): M. Haruna
  • Organizer: Japan Taiwan Bilateral Science & Technology Symposium - Frontiers in Functional Optics-
  • Place of Presentation: Center for Optical Research & Education, Utsunomiya University
  • Year and Date: 20081110-12
• [Presentation] Recent development of optical coherence tomography (2008)
  • Organizer: 3^<rd>Int'l Conf. Laser, Light-wave, Microwave Conf.(ILLMC2008)
  • Place of Presentation: Pacifico Yokohama
  • Year and Date: 20080400
• [Presentation] Maximum-intensity- projection images for dynamic analysis of mental sweating by optical coherence tomography (2008)
  • Author(s): H. Saigusa, et.al.
  • Organizer: 19-th Int'l Conf. Optical Fiber Sensors(OFS-19)
  • Place of Presentation: Perth, Australia
  • Year and Date: 20080400
• [Presentation] Dynamic imaging of small arteries and veins of human fingers by optical coherence tomography (2008)
  • Author(s): M. Kuwabara, et.al.
  • Organizer: OSA Biomedical Optics Topical Meeting(BIOMED)
  • Place of Presentation: St. Petersburg
  • Year and Date: 20080300
• [Presentation] Dynamic analysis of eccrin sweat glands on human fingertips by optical coherence tomography (2008)
  • Author(s): M. Haruna, et.al.
  • Organizer: SPIE Biomedical Optics Symposium (BiOS2008)
  • Place of Presentation: San Jose, CA, USA
  • Year and Date: 20080100
• [Presentation] OCTによる新たな精神性内部発汗とダイナミック解析 (2008)
  • Author(s): 谷川基務
  • Organizer: 日本光学会年次学術講演会OPJ2008
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2008-11-05
• [Presentation] 実時間OCTイメージングを用いた外部刺激に対する小動脈の反応追跡 (2008)
  • Author(s): 桑原光巨
  • Organizer: 日本光学会年次学術講演会OPJ2008
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2008-11-05
• [Presentation] 光コヒーレンスとモグラフィによる精神性発汗ダイナミクスの解析 (2008)
  • Author(s): 谷川基務
  • Organizer: 生体医工学シンポジウム2008
  • Place of Presentation: 大阪大学
  • Year and Date: 2008-09-19
• [Presentation] ヒト指小動脈・小静脈の実時間OCTイメージングと機能解析 (2008)
  • Author(s): 桑原光巨
  • Organizer: 生体医工学シンポジウム2008
  • Place of Presentation: 大阪大学
  • Year and Date: 2008-09-19
• [Presentation] 光コヒーレンストモグラフィを用いた発汗測定方法 (2008)
  • Author(s): 春名正光
  • Organizer: 第16回日本発汗学会総会
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2008-09-06
• [Presentation] OCTによるヒト指小動脈・小静脈の実時間イメージング (2008)
  • Author(s): 桑原光巨
  • Organizer: 第47回生体医工学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-05-08
• [Presentation] 高速OCTによるヒト指小動脈のインビボ動態観察 (2008)
  • Author(s): 桑原光巨
  • Organizer: レーザー学会第28回年次大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-01-31
• [Presentation] Dynamic OCT for physiological functions of micro organs in human fingers (2007)
  • Author(s): M. Haruna, et.al.
  • Organizer: Photonics Asia, Conf. in Health Care and Biomedical Optics
  • Place of Presentation: Photonics Asia, Conf. in Health Care and Biomedical Optics
  • Year and Date: 20071100
• [Presentation] Microscopic analysis of sweating dynamics of a human fingertip by optical coherence tomography (2007)
  • Author(s): A. Yamada, et.al.
  • Organizer: The 13-th Microoptics Conf. (MOC'07)
  • Place of Presentation: Takamatsu, Japan
  • Year and Date: 20071000
• [Presentation] Maximum-intensity- projection images of human sweat glands using optical coherence tomography (2007)
  • Author(s): Y. Ueda, et.al.
  • Organizer: The 7-th Pacific Rim Conf. on Lasers & Electro-Optics(CLEO/PR2007)
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 20070800
• [Presentation] Dynamic OCT for physiological function of venules of human fingers (2007)
  • Author(s): T. Fuji, et.al.
  • Organizer: 7-th Pacific Rim Conf. on Lasers & Electro-Optics (CLEO/PR2007)
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 20070800
• [Presentation] Quantitative analysis of mental-stress- induced sweating on a human fingertip by dynamic OCT (2007)
  • Author(s): M. Ohmi, et.al.
  • Organizer: 3-rd Asian and Pacific-Rim Symposium on BioPhotonics (APBP2007)
  • Place of Presentation: Cairns, Australia
  • Year and Date: 20070709-11
• [Presentation] An approach to high-resolution OCT analyzer for laser ablation of biological tissue (2007)
  • Author(s): M. Ohmi, et.al.
  • Organizer: 3-rd Asian and Pacific-Rim Symposium on BioPhotonics(APBP2007)
  • Place of Presentation: Cairns, Australia
  • Year and Date: 20070709-11
• [Presentation] MIP-OCTによる精神性発汗の定量解析 (2007)
  • Author(s): 三枝裕之
  • Organizer: 日本光学会年次学術講演会OPJ2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] OCTによる精神性発汗ダイナミクス解析を利用した交感神経の活動評価 (2007)
  • Author(s): 山田晃寛
  • Organizer: 日本光学会年次学術講演会OPJ2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] 安静時におけるヒト指小動脈・小静脈のOCT動態観察 (2007)
  • Author(s): 桑原光巨
  • Organizer: 日本光学会年次学術講演会OPJ2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] OCTによるヒト表皮下生理機能の動態解析 (2007)
  • Author(s): 春名正光
  • Organizer: 日本光学会年次学術講演会OPJ2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] OCTによる精神性発汗の定量解析II-SS-OCTの利用とMIPイメージの構築- (2007)
  • Author(s): 三枝裕之
  • Organizer: 第68回応用物理学会
  • Place of Presentation: 北海道工業大学
  • Year and Date: 2007-09-06
• [Presentation] OCTによる精神性発汗の定量解析I-発汗量の評価と能動汗腺の反応測定- (2007)
  • Author(s): 山田晃寛
  • Organizer: 第68回応用物理学会
  • Place of Presentation: 北海道工業大学
  • Year and Date: 2007-09-06
• [Presentation] OCTを用いた精神性発汗における能動汗腺の反応測定 (2007)
  • Author(s): 山田晃寛
  • Organizer: 第15回日本発汗学会総会
  • Place of Presentation: 埼玉医科大学
  • Year and Date: 2007-08-24
• [Presentation] OCTによる発汗ダイナミクスの解明 (2007)
  • Author(s): 近江雅人
  • Organizer: 第39回光波センシング技術研究会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2007-06-12
• [Presentation] OCTによるヒト指汗腺の動態機能解析へのアプローチ (2007)
  • Author(s): 近江雅人
  • Organizer: 第46回日本生体医工学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2007-04-26