2009 Fiscal Year Final Research Report
Designing tissue engineering scaffolds for neural stem cell transplantation through protein engineering
| Project/Area Number |
19300171
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
KATO Koichi Kyoto University, 再生医科学研究所, 准教授 (50283875)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IWATA Hiroo 京都大学, 再生医科学研究所, 教授 (30160120)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | キメラタンパク質 / 再生医療 / 中枢神経 / 細胞増殖因子 / 幹細胞移植 / バイオマテリアル / ハイドロゲル / 自己組織化 |
|---|
| Research Abstract |
This project was aimed at developing protein-based biomaterials that serve to improve the survival and engraftment of neural stem/progenitor cells transplanted into central nervous tissues for therapeutic purposes. It was shown that hydrogels made of naturally-occurring polymers such as collagen and hyaluronic acid could be suitably used as base materials. In addition, protein engineering strategies were employed to incorporate growth factors, neurotrophic factors, and/or integrin binding polypeptide domains into the base materials. We demonstrated that such approaches were quite effective for improving survival of cells embedded in the hydrogels.
|
