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2010 Fiscal Year Final Research Report

Development of next generation nano-biomaterials by cell surface engineering

Research Project

  • PDF
Project/Area Number 19300176
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKeio University

Principal Investigator

FUJIMOTO Keiji  Keio University, 理工学部, 教授 (70229045)

Project Period (FY) 2007 – 2010
Keywords細胞 / 組織工学
Research Abstract

We tried an approach to construct 2- and 3-dimensional tissues using a ligand-immobilized polymer chain as an artificial extracellular matrix. This technique based on the cell-agglomerate engineering allowed the efficient cellular coating of artificial materials with complicated shapes for improvement of biocompatibility and facilitation of tissue reconstruction. Next, we proposed a novel method for enhancing ligand-receptor binding and modifying cell surface as artificial material. So, we prepared a multi-functional polymer (polymer nano-tool) consisted of ligand, photo-reactive group, biotin and disulfide. We found that cells modified with biotin-carrying nano-tools specifically adhered to an avidin-immobilized plate and the formation of cell agglomerates was mediated by adding avidin.

  • Research Products

    (9 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Book (2 results) Remarks (1 results)

  • [Journal Article] In situ synthesis of polysaccharide nanoparticles via polyion complex of carboxymethyl cellulose and chitosan2011

    • Author(s)
      S.Kaihara, Y.Suzuki, K.Fujimoto
    • Journal Title

      Colloids and Surfaces B : Biointerfaces 8

      Pages: 343-348

    • Peer Reviewed
  • [Journal Article] The Preparation of Sugar Polymer-Coated Nanocapsules by the Layer-by-Layer Deposition on the Liposome2009

    • Author(s)
      Y.Fukui, K.Fujimoto
    • Journal Title

      Langmuir 25

      Pages: 10020-10025

    • Peer Reviewed
  • [Journal Article] Formation and recovery of a cell sheet by a particle monolayer with the surface roughness2008

    • Author(s)
      M.Miura, K.Fujimoto
    • Journal Title

      Colloids and Surfaces B : Biointerfaces 66

      Pages: 125-133

    • Peer Reviewed
  • [Journal Article] Preparation of bionanocapsules by the layer-bylayer deposition of polypeptides onto a liposome2007

    • Author(s)
      K.Fujimoto, Y.Fukui, T.Toyoda
    • Journal Title

      Macromolecules 40

      Pages: 5122-5128

    • Peer Reviewed
  • [Presentation] Simple Designs of Nanobio-Materials by Learning from Bio-Interfaces2009

    • Author(s)
      K.Fujimoto
    • Organizer
      NIMS Week 2009
    • Place of Presentation
      Tsukuba
    • Year and Date
      2009-07-22
  • [Presentation] Effect of nano-scale roughness on detachment of a cell sheet from a particle monolayer2008

    • Author(s)
      M.Miura, K.Fujimoto
    • Organizer
      The 8th World Biomaterials Congress
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      2008-05-28
  • [Book] バイオマテリアルの基礎2010

    • Author(s)
      藤本啓二,貝原祥子
    • Total Pages
      242-245
    • Publisher
      東京医学館
  • [Book] 生体に学ぶ微粒子材料の創製2008

    • Author(s)
      藤本啓二
    • Total Pages
      13-18
    • Publisher
      化学工業社
  • [Remarks] ホームページ

    • URL

      http://www.applc.keio.ac.jp/~fujimoto/lab.html

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Published: 2012-01-26   Modified: 2016-04-21  

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