Studies of fundamental technologies to realize PET diagnoses with very low radiation dose

2008 Fiscal Year Final Research Report

• Project/Area Number: 19300188
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: MURAYAMA Hideo National Institute of Radiological Sciences, 分子イメージング研究センター, チームリーダー (50166310)
• Co-Investigator(Kenkyū-buntansha): TANADA Shuji 国際医療福祉大学三田病院, 放射線科, 教授 (40116950) ; AKAHANE Keiichi 放射線医学総合研究所, 重粒子医科学センター, 研究員 (80202521) ; YAMAYA Taiga 放射線医学総合研究所, 分子イメージング研究センター, 研究員 (40392245) ; KAWAI Hideyuki 千葉大学, 理学部, 助教授 (60214590) ; SUGA Mikio 千葉大学, 工学部, 助教授 (00294281) ; KITAMURA Keishi 島津製作所, 医用機器事業部, 研究員 (30395941) ; TAKAHASHI Hiroyuki 東京大学, 工学研究科, 教授 (70216753) ; HANEISHI Hideaki 千葉大学, 工学部, 助教授 (20228521) ; HASEGAWA Tomoyuki 北里大学, 医療衛生学部, 講師 (10276181)
• Co-Investigator(Renkei-kenkyūsha): TANADA Shuji 国際医療福祉大学三田病院, 放射線科, 教授 (40116950) ; AKAHANE Keiichi 放射線医学総合研究所, 重粒子医科学センター, 研究員 (80202521) ; YAMAYA Taiga 放射線医学総合研究所, 分子イメージング研究センター, 研究員 (40392245) ; KAWAI Hideyuki 千葉大学, 理学部, 准教授 (60214590) ; SUGA Mikio 千葉大学, 工学部, 准教授 (00294281) ; KITAMURA Keishi 島津製作所, 基盤技術研究所, 主任研究員 (30395941) ; TAKAHASHI Hiroyuki 東京大学, 工学研究科, 教授 (70216753) ; HANEISHI Hideaki 千葉大学, フロンティアメディカル工学 研究開発センター, 教授 (20228521) ; HASEGAWA Tomoyuki 北里大学, 医療衛生学部, 講師 (10276181)
• Project Period (FY): 2007 – 2008
• Keywords: PET / 核医学 / 画像診断装置 / 同時計数 / 放射線検出器

Research Abstract

感度と解像度を共に向上しPET検査の超低被ばくに貢献する検出器として、検出素子配列を3次元的に光学結合するX'tal cube 検出器を提案し、その実現可能性を実証した。検出素子間に充填する接着剤の屈折率の最適化により、性能向上の図れることを実証した。
さらに検出器の層ごとにエネルギーウィンドウを設定して、被検者散乱を低減する手法と時間性能を向上させる手法を提案した。
また、体軸方向に2分割した検出器リングを離して配置し、物理的に開放された視野領域を有するOpenPET方式を新規に提案し、その実現可能性を示した。

Research Products

• [Journal Article] Parallel implementation of 3-D iterative reconstruction with intra-thread update for the jPET-D4 (2009)
  • Author(s): Lam, CF., Yamaya, T., Obi, T., Yoshida, E., Inadama, N., Shibuya, K., Nishikido, F., Murayama, H
  • Journal Title: IEEE Trans. Nucl. Sci 56,(1) Pages: 129-135
  • Peer Reviewed
• [Journal Article] Preliminary study on potential of the jPET-D4 human brain scanner for small animal imaging (2009)
  • Author(s): Yamaya, T., Yoshida, E., Toramatsu, C., Nishimura, M., Shimada, Y., Inadama, N., Shibuya, K., Nishikido, F., Murayama, H
  • Journal Title: Ann. Nucl. Med 23 Pages: 183-190
  • Peer Reviewed
• [Journal Article] A DOI-dependent extended energy window method to control balance of scatter and true events (2008)
  • Author(s): Yoshida, E., Kitamura, K., Shibuya, K., Nishikido, F., Hasegawa, T., Yamaya, T., Lam, C., Inadama, N., Murayama, H
  • Journal Title: IEEE Trans. Nucl. Sci 55,(5) Pages: 2475-2481
  • Peer Reviewed
• [Journal Article] Imaging simulations of an "OpenPET" geometry with shifting detector (2008)
  • Author(s): Yamaya, T., Inaniwa, T., Mori, S., Furukawa, T., Minohara, S., Yoshida, E., Nishikido, F., Shibuya, K., Inadama, N.,Murayama, H
  • Journal Title: Radiol. Phys. Technol 2,(1) Pages: 62-69
  • Peer Reviewed
• [Journal Article] Optical Observation of Energy Loss Distribution and Practical Range of Positrons from an 18F Water Solution in a Water-equivalent Phantom (2008)
  • Author(s): Hasegawa, T., Yoshida, E., Shibuya, K., Murayama, H
  • Journal Title: Med. Phys 36,(2) Pages: 402-410
  • Peer Reviewed
• [Journal Article] Timing resolution improvement using DOI information in a four-layer scintillation detector for TOF-PET (2008)
  • Author(s): Shibuya, K., Nishikido, F., Tsuda, T., Kobayashi, T., Lam, C., Yamaya, T., Yoshida, E., Inadama, N, Murayama, H
  • Journal Title: Nucl. Instrum. & Methods A, 593 Pages: 572-577
  • Peer Reviewed
• [Journal Article] First human brain imaging by the jPET-D4 prototype with a pre-computed system matrix (2008)
  • Author(s): Yamaya, T., Yoshida, E., Obi, T., Ito, H., Yoshikawa, K., Murayama, H
  • Journal Title: IEEE Trans. Nucl. Sci 55,(5) Pages: 2482-2492
• [Journal Article] PET 用光分配方式DOI検出器における接着剤の屈折率の影響 (2008)
  • Author(s): 大村篤史, 村山秀雄, 稲玉直子, 山谷泰賀, 吉田英治, 錦戸文彦, 澁谷憲悟, 高橋慧, 鳥居祥二
  • Journal Title: 医学物理 28 Pages: (Sup.2)41-42
• [Journal Article] APDを受光素子として用いた4層DOI-PET検出器の開発 (2008)
  • Author(s): 錦戸文彦, 稲玉直子, 吉田英治, 澁谷憲悟, ラム・チフグ, 山谷泰賀, 村山秀雄, 小田一郎
  • Journal Title: 医学物理 28 Pages: (Sup.2)45-46
• [Journal Article] 実効原子番号の低い無機シンチレータを用いた高感度PET装置の検討 (2008)
  • Author(s): 吉田英治, 北村圭司, 錦戸文彦,澁谷憲悟, 長谷川智之, 山谷泰賀, 村山秀雄
  • Journal Title: 医学物理 28 Pages: (Sup.2)47-48
• [Journal Article] 体動補正付PET画像再構成における感度画像計算法の基礎的検討 (2008)
  • Author(s): 11)木内尚子, 小林哲哉, 山谷泰賀, 長谷川智之, 村山秀雄, 菅幹生
  • Journal Title: 医学物理 28 Pages: (Sup.2)57-58
• [Journal Article] 次世代PET装置の可能性と開発の現状 (2008)
  • Author(s): 村山秀雄
  • Journal Title: 新医療 35(3) Pages: 60-63
• [Journal Article] ETーDOI-PETの研究動向と課題ー (2008)
  • Author(s): 村山秀雄
  • Journal Title: 電子情報通信学会論文誌 D, J91-D (7) Pages: 1695-1707
  • Peer Reviewed
• [Journal Article] Performance evaluation for 120 four-layer DOI block detectors of the jPET-D4 (2008)
  • Author(s): 14)Inadama, N., Murayama, H., Ono, Y., Tsuda, T., Hamamoto, M., Yamaya, T., Yoshida, E., Shibuya, K., Nishikido, F., Takahashi, K., Kawai, H
  • Journal Title: Radiol. Phys. Technol 1 Pages: 75-82
  • Peer Reviewed
• [Journal Article] A proposal of an open PET geometry. Phys (2008)
  • Author(s): Yamaya, T., Inaniwa, T., Minohara, S., Yoshida, E., Inadama, N., Nishikido, F., Shibuya, K.Lam, CF., Murayama, H
  • Journal Title: Med. Biol 53 Pages: 757-773
  • Peer Reviewed
• [Journal Article] Simplified simulation of four-layer depth of interaction detector for PET. Radiol (2008)
  • Author(s): Haneishi, H., Sato, M., Inadama, N., Murayama, H
  • Journal Title: Phys. Technol 1 Pages: 106-114
  • Peer Reviewed
• [Journal Article] Evaluation of static physics performance of the jPET-D4 with Monte Carlo simulations (2007)
  • Author(s): Hasegawa, T., Yoshida, E., Kobayashi, A., Shibuya, K., Nishikido, F., Kobayashi, T., Suga, M., Kitamura, K., Maruyama, K., Murayama, H
  • Journal Title: Phys. Med. Biol 52(1) Pages: 213-230
  • Peer Reviewed
• [Journal Article] Inter-crystal identification for a depth-sensitive detector using support vector machine for small animal PET. Nucl. Instrum (2007)
  • Author(s): 18)Yoshida, E., Kitamura, K., Kimura, Y., Nishikido, F., Shibuya, K., Yamaya, T., Murayama,H
  • Journal Title: Instrum. & Methods A, 571 Pages: 243-246
  • Peer Reviewed
• [Journal Article] Detector normalization and scatter correction for the jPET-D4: A 4-layer depth-of-interaction PET scanner. Nucl (2007)
  • Author(s): 19)Kitamura, K., Ichikawa, A., Mizuta, T., Yamaya, T., Yoshida, E., Murayama, H
  • Journal Title: Instrum. & Methods A, 571 Pages: 231-234
  • Peer Reviewed
• [Journal Article] Annihilation photon acollinearity in PET : volunteer and phantom FDG studies. Phys (2007)
  • Author(s): Shibuya, K., Yoshida, E., Nishikido, F., Suzuki, T., Tuda, T., Inadama, N., Yamaya, T., Murayama, H
  • Journal Title: Phys. Med. Biol 52, (1) Pages: 5249-5261
  • Peer Reviewed
• [Journal Article] Application of accelerators for the research and development of scintillators (2007)
  • Author(s): Shibuya, K., Koshimizu, M., Asai, K., Muroya, Y., Katsumura, Y., Inadama, N., Yoshida, E., Nishikido, F., Yamaya, T., Murayama, H
  • Journal Title: Rev. Sci. Instr 78 Pages: 083303 1-7
  • Peer Reviewed
• [Journal Article] 頭部用試作機 jPET-D4 における計数率特性の改善 (2007)
  • Author(s): 吉田英治, 大村知秀, 小林彩子, 錦戸文彦, 山谷泰賀, 北村圭司, 村山秀雄
  • Journal Title: 医学物理 27 Pages: (Sup. 2)76- 77
• [Journal Article] 検出器エラーを補正する核医学画像再構成手法の提案 (2007)
  • Author(s): 山谷泰賀, 吉田英治, 村山秀雄
  • Journal Title: 医学物理 27 Pages: (Sup. 2)80- 81
• [Journal Article] 頭部用試作機 jPET-D4 による小動物PETイメージングの可能性. (2007)
  • Author(s): 24)山谷泰賀, 吉田英治, 稲玉直子, 澁谷憲悟, 錦戸文彦, ラム・チフグ, 長谷川智之, 西村義一, 西村まゆみ, 島田義也, 村山秀雄
  • Journal Title: 医学物理 27 Pages: (Sup. 2)82- 83
• [Journal Article] PETイメージングにおけるDOI情報とTOF情報の併用による画質改善 (2007)
  • Author(s): 小林哲哉, 山谷泰賀, 高橋悠, 北村圭司, 長谷川智之, 村山秀雄, 菅幹生
  • Journal Title: 医学物理 27 Pages: (Sup. 2)84- 85
• [Journal Article] 近接撮影型DOI-PET装置に適した3次元観測モデルの提案 (2007)
  • Author(s): 高橋悠, 山谷泰賀, 小林哲哉, 北村圭司, 長谷川智之, 村山秀雄, 菅幹生
  • Journal Title: 医学物理 27 Pages: (Sup. 2)86- 87
• [Journal Article] 次世代陽電子放射型断層画像診断装置の開発 (2007)
  • Author(s): 村山秀雄
  • Journal Title: 応用物理 76(4) Pages: 375-382
  • Peer Reviewed
• [Presentation] Development of a prototype system of a small bore DOI-PET scanner (2008)
  • Author(s): Nishikido, F. (Murayama, H)
  • Organizer: 2008 IEEE Nuc. Sci. Sympo. & Med. Imag. Conf
  • Place of Presentation: Dresden, Germany
  • Year and Date: 2008-11-24
• [Presentation] Preliminary study on a new DOI PET detector with limited number of photo-detectors (2008)
  • Author(s): Yazaki, Y. (Murayama, H)
  • Organizer: The 5th Korea-Japan Joint Meeting on Medical Physics
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-09-11
• [Presentation] Application of scintillation crystals cut as a trianglar prism for a PET detector (2008)
  • Author(s): Inadama, N. (Murayama, H)
  • Organizer: The 5th Korea-Japan Joint Meeting on Medical Physics
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-09-11
• [Presentation] Comparison of two DOI crystal blocks composed of different GSO types for optimization of a DOI PET/optical imaging detector (2008)
  • Author(s): Osada, H. (Murayama, H)
  • Organizer: The 5^<th> Korea-Japan Joint Meeting on Medical Physics
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-09-11
• [Presentation] A novel point-like radioactive source for performance evaluation of PET scanners (2008)
  • Author(s): Hasegawa, T
  • Organizer: The 5^<th> Korea-Japan Joint Meeting on Medical Physics
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-09-11
• [Presentation] Feasibility study of a highly sensitive LaBr3 PET scanner basedon the DOI-dependent extended-energy window (2008)
  • Author(s): Yoshida, E. (Murayama, H)
  • Organizer: The 8^<th> Intern. Conf. On Position Sensitive Detectors - PSD8
  • Place of Presentation: Glasgow, United Kingdom
  • Year and Date: 2008-09-04
• [Presentation] Parallel Implementation of 3-D Dynamic Iterative Reconstruction with Intra-node Image Update for the jPET-D4. (2007)
  • Author(s): Lam, C.F. (Yamaya, T.)
  • Organizer: 2007 IEEE Nucl. Sci. Sympo. & Med. Imag. Conf
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2007-11-02
• [Presentation] A DOI-dependent extended energy window method to control balance of scatter and true events (2007)
  • Author(s): Yoshida, E. (Murayama, H)
  • Organizer: 2007 IEEE Nucl. Sci. Sympo. & Med. Imag. Conf
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2007-11-01
• [Presentation] DOI Encoding on the PET Detector Using 2 X 2 PMT Array (2007)
  • Author(s): Inadama, N. (Murayama, H)
  • Organizer: 2007 IEEE Nucl. Sci. Sympo. & Med. Imag. Conf
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2007-11-01
• [Presentation] 3D PET image reconstructin with on-the-fly system matrix generation accelerated by utilizing shift and symmetry properties. The 9th Intern (2007)
  • Author(s): Lam, CF. (Yamaya, T.)
  • Organizer: Meeting on Fully Three-Dimensional Image Reconst
  • Place of Presentation: Radiol. And Nucl. Med., Lindau, Germany
  • Year and Date: 2007-07-11
• [Presentation] Improvement of PET image quality using DOI and TOF information (2007)
  • Author(s): Kobayashi, T. (Suga, M.)
  • Organizer: The 9^<th> Intern. Meeting on Fully Three-Dimensional Image Reconst
  • Place of Presentation: Radiol. And Nucl. Med., Lindau, Germany
  • Year and Date: 2007-07-11
• [Presentation] Implementation of 3D image reconstruction with a pre-computed system matrix for the jPET-D4. The 9th Intern (2007)
  • Author(s): Yamaya, T
  • Organizer: Meeting on Fully Three-Dimensional Image Reconst
  • Place of Presentation: Radiol. And Nucl. Med., Lindau, Germany
  • Year and Date: 2007-07-10
• [Book] 平成20年度次世代PET研究報告書 (2009)
  • Author(s): 村山秀雄、山谷泰賀
  • Total Pages: 146
  • Publisher: 放射線医学総合研究所
• [Book] 平成19年度次世代PET研究報告書 (2008)
  • Author(s): 菅野 巖、村山秀雄
  • Total Pages: 146
  • Publisher: 放射線医学総合研究所
• [Patent(Industrial Property Rights)] 開放型PET装置γ線を放出する陽電子崩壊核種の放射能絶対測定方法、放射線検出器集合体の検出効率決定方法、及び、放射線測定装置の校正方法 (2008)
  • Inventor(s): 佐藤泰, 村山秀雄, 山田崇裕, 長谷川智之, 織田圭一
  • Industrial Property Number: 2008-306087
  • Filing Date: 2008-12-01
• [Patent(Industrial Property Rights)] DOI型放射線検出器 (2008)
  • Inventor(s): 稲玉直子, 村山秀雄, 澁谷憲悟, 錦戸文彦, 津田倫明
  • Industrial Property Number: PCT/JP2008/062804
  • Filing Date: 2008-07-16
• [Patent(Industrial Property Rights)] 放射線検出方法、装置、及び、陽電子放射断層撮像装置 (2008)
  • Inventor(s): 澁谷憲悟, 山谷泰賀, 稲玉直子, 錦戸文彦, 吉田英治, 村山秀雄
  • Industrial Property Number: PCT/JP2008/057035
  • Filing Date: 2008-04-09
• [Patent(Industrial Property Rights)] 開放型PET装置 (2008)
  • Inventor(s): 山谷泰賀, 稲玉直子, 村山秀雄
  • Industrial Property Number: PCT/JP2008/56451
  • Filing Date: 2008-04-01
• [Patent(Industrial Property Rights)] 四角柱形セルの配置器具及び配置方法 (2008)
  • Inventor(s): 村山秀雄, 稲玉直子, 奥野敦
  • Industrial Property Number: 特許第4187093号
  • Acquisition Date: 2008-09-19
• [Patent(Industrial Property Rights)] 入射位置検出装置 (2008)
  • Inventor(s): 高橋浩之, 村山秀雄, 石津崇章
  • Industrial Property Number: 特許第4178232号
  • Acquisition Date: 2008-09-05
• [Patent(Industrial Property Rights)] 深さ位置認識型放射線検出器 (2008)
  • Inventor(s): 長谷川智之, 村山秀雄
  • Industrial Property Number: 特許第4168138号
  • Acquisition Date: 2008-08-15
• [Patent(Industrial Property Rights)] エネルギーと位置情報を利用した放射線検出方法及び装置 (2007)
  • Inventor(s): 吉田英治,澁谷憲悟,山谷泰賀,村山秀雄,北村圭司
  • Industrial Property Number: PCT/JP2007/066940
  • Filing Date: 2007-08-30
• [Patent(Industrial Property Rights)] 放射線位置検出器 (2007)
  • Inventor(s): 稲玉直子, 村山秀雄, 澁谷憲悟, 錦戸文彦, 大井淳一, 津田倫明
  • Industrial Property Number: 特願2007-221441号
  • Filing Date: 2007-08-28
• [Patent(Industrial Property Rights)] エネルギーと位置情報を利用した放射線検出方法及び装置 (2007)
  • Inventor(s): 吉田英治, 澁谷憲悟, 山谷泰賀, 村山秀雄
  • Industrial Property Number: 特願2007-112925
  • Filing Date: 2007-04-23