2009 Fiscal Year Final Research Report
Research and development of a therapeutic exercise preconditioning for muscle atrophy and circulatory failure with non-insulin-dependent diabetes mellitus
| Project/Area Number |
19300196
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
TAKEDA Isao Himeji Dokkyo University, 医療保健学部, 教授 (00163402)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Akihiko 京都大学, 大学院・人間環境学研究科, 教授 (90184548)
KAJIYA Fumihiko 川崎医療福祉大学, 医療技術学部, 教授 (70029114)
SUGAWARA Motoaki 姫路獨協大学, 医療保健学部, 教授 (60010914)
MURAKAMI Shinichiro 姫路獨協大学, 医療保健学部, 教授 (30454763)
FUJINO Hidemi 神戸大学, 大学院・保健学研究科, 教授 (20278998)
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| Project Period (FY) |
2007 – 2009
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| Keywords | リハビリテーション / 運動療法 / 糖尿病 / 微小循環 / プレコンディショニング |
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| Research Abstract |
Exercise training has long been utilized as one of therapy in the non-insulin-dependent diabetes mellitus. The effects of a therapeutic exercise preconditioning on the myocyte and the microcirculation of skeletal muscle in diabetic rats was investigated. The preconditioning consisted of exercise at either low-(aerobic) or Hi-(unaerobic) intensity and included five 60 or 30 min sessions per week for 3 weeks, respectively. Both treated diabetic rats exhibited a decrease in plasma glucose, glycohemoglobin, and reactive oxygen species (ROS) compared with those of the diabetic rats but did not completely normalize levels. The capillary volume in diabetic muscle was significantly less, i.e., capillary regression. In three exercise-trained diabetic muscles, the capillary volumes were increased toward control levels and completely normalize levels. In summary, the results of the present study provide evidence for the effectiveness of exercise training in reducing some of the muscle circulatory complications associated with diabetes mellitus.
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Research Products
(41 results)
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[Journal Article] Exercise exerts neuroprotective effects on Parkinson's disease model of rats2010
Author(s)
Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan W, Kadota T, Wang F, Baba T, Tayra JT, Morimoto T, Jing M, Kikuchi Y, Kuramoto S, Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I, Furuta T, Date I
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Journal Title
Brain Res 1310C
Pages: 200-207
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