2009 Fiscal Year Final Research Report
Is an increase in GLUT4 mRNA in response to exercise training mediated by MEF2?
| Project/Area Number |
19300225
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | National Institute of Health and Nutrition |
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Principal Investigator |
EZAKI Osamu National Institute of Health and Nutrition, 基礎栄養プログラム, プログラムリーダー (90191923)
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| Project Period (FY) |
2007 – 2009
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| Keywords | インスリン抵抗性 / GLUT4 / 運動 / 高脂肪食 / トランスジェニックマウス / 筋肉 / 脂肪組織 |
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| Research Abstract |
To examine whether MEF2 was involved in an increase in GLUT4 mRNA by exercise training, MEF2 overexpressed transgenic mice in skeletal muscles were produced. MEF2 overexpressed mice did not increase GLUT4 mRNA in skeletal muscles. Transcription co-activators, PGC-1α-b and PGC-1α-c, are increased by exercise training and activate MEF2. However, PGC-1α-b or PGC-1α-c overexpressed mice did not increase GLUT4 mRNA in skeletal muscles. These data suggested that MEF2 was not involved in an increase in GLUT4 mRNA by exercise training.
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[Journal Article] The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.2010
Author(s)
Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y
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Journal Title
Biochem J. 427
Pages: 171-178
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[Journal Article] Ubiquitin C-terminal hydrolase-L3-Knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.2009
Author(s)
Setsuie R, Suzuki M, Kabuta T, Fujita H, Miura S, Ichihara N, Yamada D, Wang YL, Ezaki O, Suzuki Y, Wada K
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Journal Title
FASEB J. 23
Pages: 4148-4157
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