2009 Fiscal Year Final Research Report
The study on functional food using oxidative stress marker, hydroxyoctadecadienoic acid and 7-hydroxycholesterol
| Project/Area Number |
19300256
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
YOSHIDA Yasukazu National Institute of Advanced Industrial Science and Technology, 健康工学研究センター, 研究センター付 (90358333)
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| Co-Investigator(Kenkyū-buntansha) |
NIKI Etsuo 独立行政法人産業技術総合研究所, 健康工学研究センター, 顧問 (20011033)
AKAZAWA Yoko 独立行政法人産業技術総合研究所, 健康工学研究センター, 特別研究員 (50549897)
SAITO Yoshiro 独立行政法人産業技術総合研究所, ヒューマンストレスシグナル研究センター, 研究員 (70357060)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 機能性食品 / 酸化ストレスマーカー / ヒドロキシリノール酸 / ヒドロキシコレステロール / タンパク質酸化修飾 / 酸化DJ-1 |
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| Research Abstract |
Lipid peroxidation products have received a great deal of attention for the partical application to clinical use as bio-markers. To assess the antioxidative role of functional foods and antioxidants, vitamin E and BO-653, in a mouse model and culture cell using lipid peroxidation and protein oxidation products. In the present study, we proposed that lipid peroxidation (tHODE and tOHCh) and protein oxidation are indeed good markers for the detection of progression of oxidative stress and effect of functional foods.
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[Journal Article] Antioxidant effects of 2, 3-dihydro-5-hydroxy-4, 6-di-tert-butyl-2, 2-dipentylbenzofur an and a-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol.2007
Author(s)
吉田康一, 早川三恵子, 伊藤奈々子, 羽渕洋子, 井上ルリ子, Zhi-Hua Chen, Jiaofei Cao, Cynshi Osamu, Jishage Kou-Ichi, 二木鋭雄
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Journal Title
Biochemical Pharmacology vol.74
Pages: 1010-1019
Peer Reviewed
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