2009 Fiscal Year Self-evaluation Report
Study on DNA repair mechanism and mutagenesis using novel cell lines
| Project/Area Number |
19310035
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Ibaraki University |
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Principal Investigator |
TAUCHI Hiroshi Ibaraki University, 理学部, 教授 (70216597)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 修復 / 放射線影響 / DNA損傷 |
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| Research Abstract |
本研究課題では、相同組換え(HR)と非相同末端結合(NHEJ)という2つのDSB修復系路に関わるタンパク機能を、修復精度の制御という新たな視点から解明することを目指している。具体的には、Ku70機能とNBS1複合体との相互作用がDNA損傷修復効率に与える影響、Ku70とNBS1の相互作用と突然変異との関係、HRによるDSB修復効率と細胞周期ならびに修復関連タンパク量との関係、の3点を明らかにする。
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[Journal Article] Two major factors involved in the reverse dose-rate effect for somatic mutation induction are the cell cycle position and LET value2009
Author(s)
Tauchi, H., Waku, H., Matumoto, E., Yara, S., Okumura, S., Iwata,Y., Komatsu, K., Frusawa, Y., Eguchi-Kasai, K., Tachibana, A.
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Journal Title
J. Radiat. Res. 50
Pages: 441-448
Peer Reviewed
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[Journal Article] Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance to DNA-protein crosslinks in mammalian cells2009
Author(s)
Nakano, T., Katafuchi, A., Matsubara, M., Terato, H., Tsuboi, T., Masuda, T., Tatsumoto, M., Pack, S.-P. Makino, K., Croteau, D. L., Van Houten, B., Iijima, K., Tauchi, H., Ide, H.
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Journal Title
J. Biol. Chem. 284
Pages: 27065-27076
Peer Reviewed
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[Journal Article] NBS1 regulates a novel apoptotic pathway through Bax activation2008
Author(s)
Iijima, K., Muranaka, C., Kobayashi, J., Sakamoto, S., Komatsu, K., Matsuura, S., Kubota, N., Tauchi, H.
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Journal Title
DNA Repair 7
Pages: 1705-1716
Peer Reviewed
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