2009 Fiscal Year Final Research Report
Research of antibacterial chemicals in marine sponge and development of lead compounds for therapy in infectious diseases
| Project/Area Number |
19310042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
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Principal Investigator |
HARAGUCHI Koichi Daiichi University, College of Pharmaceutical Sciences, 薬学部, 教授 (00258500)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Yoshihisa 徳島文理大学, 香川薬学部, 准教授 (90161132)
MATSUBARA Futoshi 第一薬科大学, 薬学部, 准教授 (60368975)
OGUMA Takatoshi 徳島文理大学, 香川薬学部, 教授 (20446074)
NISHIMURA Eri 第一薬科大学, 薬学部, 助手 (80412550)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 海綿 / 臭素化合物 / 抗菌活性 / リード化合物 / 創薬 |
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| Research Abstract |
We developed the APCI-LC/MS/MS and ECNI-GC/MS methods for screening of antibacterial brominated products in marine sponges (e.g. Lamellodysidea sp.) from Palau, Micronesia. Broad antibacterial spectra of phenolic products such as tetrabromocatechol, 2,2'-dihydroxy-BB80 and 2'-hydroxy-6-methoxy-BDE68 were observed and these products showed growth inhibitory effects against E. Faecalis, E. Faecius, S. aureus, MRSA and S. pyogenes. These components are expected for lead compounds of antibacterial agents.
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[Journal Article] 4-Hydroxy-2, 2', 3, 4', 5, 5', 6-heptachlorobiphenyl-mediated decrease in serum thyroxine level in mice occurs through increase in accumulation of thyroxine in the liver.2009
Author(s)
Kato Y, Haraguchi K, Kubota M, Seto S, Ikushiro S, Sakaki T, Koga N, Yamada S, Degawa M.
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Journal Title
Drug Metab. Dispos. 37
Pages: 2095-2102
Peer Reviewed
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