2009 Fiscal Year Final Research Report
Probabilistic Models of the Marginal Distribution of Gene Expression
| Project/Area Number |
19310128
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
HORTON Paul National Institute of Advanced Industrial Science and Technology, 生命情報工学研究センター, 研究チーム長 (00371071)
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| Co-Investigator(Kenkyū-buntansha) |
HORIMOTO Katsuhisa 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 研究チーム長 (40238803)
ABURATANI Sachiyo 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 研究員 (10361627)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 遺伝子発現 / 次世代シーケンサー / TSS-Seq法 / 転写頻度 / Quality Scores |
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| Research Abstract |
1) Established a method for automatically constructing probabilistic mixture models of gene expression from microarray data. 2) Performed analysis on the marginal distribution of genes and hypothesized that the noise in microarray experiments hinders proper analysis. 3) Established a method for correcting the influence of misreads to allow next-generation sequencer mRNA sequence data to be used for precise analysis of gene expression.
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