2009 Fiscal Year Final Research Report
Studies on the SUMO modification system : Towards understanding regulation of the nuclear function and structure
| Project/Area Number |
19310131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied genomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
SAITOH Hisato Kumamoto University, 大学院・自然科学研究科, 教授 (50211925)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 翻訳後修飾 / スモ / SUMO / エピゲノム / クロマチン |
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| Research Abstract |
The small ubiquitin-related modifier 2/3 (SUMO2/3) can be post-translationally conjugated to a wide variety of proteins constituting chromatin, the platform for genetic and epigenetic regulation. Nevertheless, it is unclear how SUMO2/3 and SUMO2/3 modified proteins are delivered to the chromatin fibers. We report that the largest subunit of chromatin assembly factor 1 (CAF-1), human p150, which, in the context of DNA replication, promotes chromatin assembly, interacts directly and preferentially with SUMO2/3. Our findings suggest an expanded role of p150 as a SUMO2/3-interacting factor, and raise the intriguing possibility that p150 plays a role in promoting delivery of SUMO2/3 or SUMO2/3 modified proteins (or both) on chromatin fibers during replication.
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Research Products
(41 results)
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[Presentation] The p150 subunit of CAF-1 causes association of SUMO2/3 with DNA replication foci2010
Author(s)
J. Uwada, N. Tanaka, Y. Yamaguchi, Y. Uchimura, K. Shibahara, M. Nakao, H. Saitoh
Organizer
Poster #47 5th International Conference "SUMO, Ubiquitin, Ubl proteins: Implications for Human Diseases at The University of Texas M. D
Place of Presentation
Anderson Cancer Center, Houston, TX
Year and Date
20100210-20100213
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[Presentation] SUMO修飾によるクロマチンとエピゲノム制御2008
Author(s)
宇和田淳介, 関大亮, 田中新菜, 橋口耕太郎, 笹野貴司, 河崎梓, 藤光由佳, 小幡晋平, 北野健, 岩井一宏, 斉藤寿仁
Organizer
第31回日本分子生物学会年会, 第81回日本生化学会大会合同大会
Place of Presentation
神戸・神戸ポートアイランド(口頭発表)
Year and Date
20081209-20081212
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[Presentation] The SUMO Signaling in the Regulation of Epigenome and Nuclear Functions: SUMO2/3 as a Signal for Protein Degradation?2008
Author(s)
Sasano, T., Hashiguchi, K., Fujimitsu, Y., Uwada, J., Seki, D., Obata, S., Iwai, K., Saitoh, H
Organizer
ZOMES国際シンポ
Place of Presentation
横浜(Invited Speaker)
Year and Date
20081111-20081114
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[Presentation] Regulation of Nuclear Function by the SUMO-SIM Interactions2008
Author(s)
Fujimitsu, Y., Sasano, T., Hashiguchi, K., Tanaka, N., Uwada, J., Iwai, K., Saitoh, H
Organizer
Cold Spring Harbor Laboratory Meeting on Dynamic Organization of Nuclear Function, Cold Spring Harbor CSHLミーティング
Place of Presentation
NY, USA(Poster presentation)
Year and Date
20080917-20080922
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[Presentation] Insights into Regulation and the Role of SUMO Modification of MBD1, a Member of the Methyl CpG DNA-binding Protein Family2008
Author(s)
Uwada, J., Uchimura, Y., Nakao, M., Saitoh, H
Organizer
4th International Conference on Ubiquitin, Ubiquitin-like proteins and Cancer
Place of Presentation
TX, USA(Poster)
Year and Date
20080207-20080209
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