2009 Fiscal Year Final Research Report
Search for Natural Products Which Enhance the Effect of Tumor Suppressor Protein
| Project/Area Number |
19310140
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Chiba University (2008-2009)
Kanazawa University (2007) |
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Principal Investigator |
TSUKAMOTO Sachiko Chiba University, 大学院・生命科学研究部, 教授 (40192190)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ユビキチン / プロテアソーム / がん抑制遺伝子産物 / 抗がん剤 / p53 / 天然低分子化合物 / 海洋生物 |
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| Research Abstract |
p53 plays an important role on suppression of tumor, and the drugs which enhance the effect of p53 will treat a various cancer. In this study, we search for compounds, which inhibit the interactions of p53-Hdm2 and Ubc13-Uev1A from marine organisms.
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