2009 Fiscal Year Final Research Report
Development of chemicals that control the glutathione metabolism and oxidative stress and their use for chemical biology
| Project/Area Number |
19310143
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Kyoto University |
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Principal Investigator |
HIRATAKE Jun Kyoto University, 化学研究所, 教授 (80199075)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Bunta 京都大学, 化学研究所, 助教 (10544637)
MIZUTANI Masaharu 神戸大学, 大学院・農学研究科, 准教授 (60303898)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Bunichi 東洋大学, 生命科学部, 准教授 (50324695)
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| Project Period (FY) |
2007 – 2009
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| Keywords | グルタチオン / γ-グルタミルシステイン合成酵素 / γ-グルテミルシランスペプチダーゼ / 遷移状態アナログ阻害剤 / 酸化ストレス制御 / 病原性連鎖球菌 / アンチェイジング化粧品 / 急性腎障害軽減 |
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| Research Abstract |
Thisstudy concerns the development and applications of chemical tools that regulate the redox status of cells by designing and synthesizing specific inhibitors of γ-glutamylcysteine synthetase (GCS), therate-determiningenzymeinglutathione synthesis, and γ-glutamyl transpeptidase (GGT), the initial andprimarily important enzyme in the glutathione metabolism.The inhibitors are to serve as chemical probes to investigate the relationships between cell redox potential and various diseases and as leads to agrochemicals and pharmaceuticals, as well as to antiaging cosmetics.
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