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2010 Fiscal Year Final Research Report

Development of Glycoconjugated Hybrid Metal Complexes for the Next-Generation Advanced Medical Care

Research Project

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Project/Area Number 19350031
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Inorganic chemistry
Research InstitutionKyoto University (2008-2010)
Nara Women's University (2007)

Principal Investigator

YANO Shigenobu  Kyoto University, 物質創成科学研究科, 客員教授 (60011186)

Co-Investigator(Kenkyū-buntansha) OBATA Makoto  山梨大学, 大学院・医学工学総合研究部, 准教授 (70343267)
MORIMOTO Keiko  奈良女子大学, 生活環境学部, 教授 (30220081)
OOI Hiromi  京都大学, 産官学連携センター, 助教 (80452522)
URUMA Yoshiyuki  米子工業高等専門学校, 物質工学科, 助教 (70442457)
AKASHI Haruo  岡山理科大学, 自然科学研究所, 教授 (30221708)
SHIBAHARA Takashi  岡山理科大学, 理学部, 教授 (30122386)
Project Period (FY) 2007 – 2010
Keywords金属錯体 / 糖 / 医療 / 光線力学療法 / 制がん剤 / 光増感剤 / バイオメカニズム
Research Abstract

We have succeeded in isolation of high-performance sugar linked photosensitizers for photodynamic therapy and anticancer novel metal complexes which might be available for next-generation advanced medical care.

  • Research Products

    (25 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (4 results) Book (1 results)

  • [Journal Article] The development of the novel photodynamic therapy with glycoc onjugated chlorine for gastric and colon cancer2011

    • Author(s)
      M.Tanaka, H.Kataoka, M.Mabuchi, S.Sakuma, S.Takahashi, R.Tsujii, H.Akashi, S.Yano, A.Morita, T.Joh
    • Journal Title

      Anticancer Res 31(3)

      Pages: 763-769

    • Peer Reviewed
  • [Journal Article] Effect and Mechanism of a New Photodynamic Therapy with Glycoconjugated Fullerene2010

    • Author(s)
      E.Otake, S.Sakuma, K.Torii, A.Maeda, H.Ohi, S.Yano, A.Morita
    • Journal Title

      Photchem. Photobiol 86

      Pages: 1356-1363

    • Peer Reviewed
  • [Journal Article] Mitochondrial mode of action of a thymidine-based cisplatin analog breaks resistance in cancer cells2010

    • Author(s)
      L.A.Onambele, D.Koth, J.A.Czaplewska, Ul.S.Schubert, H.Gorls, S.Yano, M.Obata, M.Gottschaldt, A.Prokop
    • Journal Title

      Eur.J.Chem. 16

      Pages: 14498-14505

    • Peer Reviewed
  • [Journal Article] Sugar-selective enrichment of D-glucose substituted ruthenium bipyridyl complex inside HepG2 cancer cells2010

    • Author(s)
      M.Gottschaldt, U.S.Schubert, .S.Rau, S.Yano, J.G.Vos, T.Kroll, J.Clement, I.Hilger
    • Journal Title

      ChemBioChem. 11

      Pages: 649-652

    • Peer Reviewed
  • [Journal Article] Cationic technetium and rhenium complexes with pendant carbohydrates2010

    • Author(s)
      C.L.Ferreira, F.L.N.Marques, M.R.Y.Okamoto, A.H.Otake, Y.Sugai, Y.Mikata, T.Storr, M.Bowen, S.Yano, M.Adam, R.Chammas, C.Orvig
    • Journal Title

      Appl.Radiat. Isotopes 68

      Pages: 1087-1093

    • Peer Reviewed
  • [Journal Article] Control of aggregation property of tris(maltohexaose)-linked porphyrins with an alkyl chain2010

    • Author(s)
      Y.Mikata, T.Sawaguchi, T.Kakuchi, M.Gottschaldt, U.S.Schubert, H.Ohi, S.Yano
    • Journal Title

      Eur.J.Org.Chem.

      Pages: 663-671

    • Peer Reviewed
  • [Journal Article] Synthesis, Photophysical Properties and Sugar-Dependent In Vitro Photocytotoxicity of Pyrrolidine-Fused Chlorins bearing S-Glycosides2009

    • Author(s)
      S.Hirohara, M.Obata, H.Alitomo, K.Sharyo, T.Ando, M.Tanihara, S.Yano
    • Journal Title

      J.Phtochem. Photobiol, B : Biol. 97

      Pages: 22-33

    • Peer Reviewed
  • [Journal Article] EXAFS Study on Reaction of Anti-tumor Platinum Complexes with Reduced Glutathione2009

    • Author(s)
      M.Obata, M.Harada, H.Ohi, S.Hirohara, M.Gottchaldt, S.Yano
    • Journal Title

      Chem.Pharm.Bull. 57

      Pages: 1107-1109

    • Peer Reviewed
  • [Journal Article] N-Glycoside Complexes of Nickel (II) ; Probing Carbohydrate-Transition Metal Interactions2009

    • Author(s)
      D.Jones, M.van Holst, S.Yano, T.Tanase, J.Aldrich-Wright
    • Journal Title

      Aust.J.Chem. 62

      Pages: 265-268

    • Peer Reviewed
  • [Journal Article] Rhenium and 99m-technetium complexes of monosaccharide based tripodal triamines as potential radio imaging agents2009

    • Author(s)
      M.Gottschaldt, C.Bohlender, D.Muller, I.Klette, R.P.Baum, S.Yano, U.S.Schubert
    • Journal Title

      Dalton Trans

      Pages: 5148-5154

    • Peer Reviewed
  • [Journal Article] In Vitro Heavy-Atom Effect of Palladium (II) and Platinum (II) Complexes of Pyrrolidine-Fused Chlorin in Photodynamic Therapy2009

    • Author(s)
      M.Obata, S.Hirohara, R.Tanaka, I.Kinoshita, K.Ohkubo, S.Fukuzumi, M.Tanihara, S.Yano
    • Journal Title

      J.Med.Chem. 52

      Pages: 2747-2753

    • Peer Reviewed
  • [Journal Article] Synthesis and Photocytotoxicity of S-Glucosylated 5,10,15,20-Tetrakis(tetrafluorophenyl)porphyrin Metal Complexes as Efficient 1^<O>_2-Generating Glycoconjugates2009

    • Author(s)
      S.Hirohara, M.Obata, H.Alitomo, K.Sharyo, T.Ando, S.Yano, M.Tanihara
    • Journal Title

      Bioconjugate Chem. 20

      Pages: 944-952

    • Peer Reviewed
  • [Journal Article] Preaparation and conformational analysis of C-glycosylβ^<2>- and β/β^<2>-peptides2009

    • Author(s)
      Y.Inaba, T.Kawakami, S.Alimoto, T.Ikegami, T.Takeuchi, T.Nakazawa, S.Yano, Y.Mikata
    • Journal Title

      Carbohydr. Res. 344

      Pages: 613-626

    • Peer Reviewed
  • [Journal Article] Estrogen Replacement Suppresses Pressor Response and Oxidative Stress Induced by Cage-switch Stress in Ovariectomized Rats2008

    • Author(s)
      K.Morimoto, S.Yan (8人)
    • Journal Title

      Ann.N.Y.Acad.Sci. 1148

      Pages: 213-218

    • Peer Reviewed
  • [Journal Article] Structure-Photodynamic Effect Relationships of 24 Glycoconjugated Photosensitizers in HeLa Cells2008

    • Author(s)
      S.Hirohara, M.Obata, H.Alitomo, K.Sharyo, S.Ogata, C.Ohtsuki, S.Yano, T.Ando, M.Tanihara
    • Journal Title

      Biol.Pharm. Bull. 31

      Pages: 2265-2272

    • Peer Reviewed
  • [Journal Article] Syntheses, structural characterization and photophysical properties of 4-(2-pyridyl)-1, 2, 3-triazole rhenium (I) complexes2008

    • Author(s)
      M.Obata, A.Kitamura, A.Mori, C.K.J.A.Czaplewska, R.Tanaka, I Kinoshita, T.Kusumoto, H.Hashimoto, M.Harada, Y.Mikata, T.Funabiki, S.Yano
    • Journal Title

      Dalton Trans.

      Pages: 3292-3300

    • Peer Reviewed
  • [Journal Article] Asymmetric Sulfur Atom Coordination in a Copper (II) Dipicolylamine (DPA) Complex with a Thioglycoside Ligand2007

    • Author(s)
      Y.Sugai, T Fujimoto, S.Fujii, S Yano, Y.Mikata,
    • Journal Title

      Dalton Trans.

      Pages: 3705-3709

    • Peer Reviewed
  • [Journal Article] Synthesis and structure of novel sugar substituted bipyridine complexes of rhenium and 99m-technetium2007

    • Author(s)
      M.Gottschaldt, S.Yano, 他5名
    • Journal Title

      Chem.Eur.J. 13

      Pages: 10273-10280

    • Peer Reviewed
  • [Journal Article] Sugar-dependent photodynamic effect of glycoconjugated porphyrins : A study on photocytotoxicity, photophysical properties and binding behavior to bovine serum albumin (BSA)2007

    • Author(s)
      M.Obata, S.Yano, 他7名
    • Journal Title

      Biochim. Biophys. Acta 1770

      Pages: 1204-1211

    • Peer Reviewed
  • [Journal Article] Current states and future views in photodynamic therapy

    • Author(s)
      S.Yano, S.Hirohara, M.Obata, Y.Hagiya, S.Ogura, A.Ikeda, H.Kataoka, M.Tanaka, T.Joh
    • Journal Title

      J.Photochem. Photobiol., C (in press)

    • Peer Reviewed
  • [Presentation] 高性能光線力学療法用糖鎖連結光増感剤の開発2011

    • Author(s)
      S.Yano
    • Organizer
      高分子北海道支部講演会
    • Place of Presentation
      札幌
    • Year and Date
      2011-02-01
  • [Presentation] Remarkable Photodynamic Effect of Glycoconjugated C60 Fullerenes2008

    • Author(s)
      S.Yano
    • Organizer
      The 8^<th> International Porphyrin-Heme Symposium
    • Place of Presentation
      Matsue (Invited)
    • Year and Date
      2008-10-16
  • [Presentation] Development of glycoconjugated photosensitizers for photodynamic Therapy2007

    • Author(s)
      S.Yano
    • Organizer
      7^<th> International Conference on Tetrapyrrole Photoreceptors in Photosynthetic Organisms
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-12-11
  • [Presentation] Recent Progress of Glycoconjugated Metal Complexes and their Functions2007

    • Author(s)
      S.Yano
    • Organizer
      2007-(28^<th>)-International Conference on Science & Technology
    • Place of Presentation
      Prague, Czech Republi
    • Year and Date
      2007-07-05
  • [Book] J.F.Allen, E.Gantt, J.H.Golbeck, and B.Osmond, Eds., Springer. (Syntheses and Photochemical Properties of Trimanganese Compexes Containing Naphtyl Moieties)2008

    • Author(s)
      S.Yano, M.Nakai, H.Ohi, T.Funabiki, R.Tanaka, I.Kinoshita, M.Obata
    • Total Pages
      1285-1288
    • Publisher
      Photosynthesis. Energy from the sun

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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