2009 Fiscal Year Final Research Report
Construction of New Chiral Skeletons Using by Catalytic Cycloaddition
| Project/Area Number |
19350052
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Synthetic chemistry
|
|---|
| Research Institution | Waseda University |
|---|
Principal Investigator |
SHIBATA Takanori Waseda University, 理工学術院, 教授 (80265735)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | 有機合成 / 遷移金属 / 錯体触媒 |
|---|
| Research Abstract |
Transition metal catalyzed-reactions realize efficient and useful synthetic transformations. In particular, transition metals with chiral ligands can induce high enantioselectivity, and various types of chiral skeletons can be synthesized. I have focused on the development of chiral transition metal-catalyzed cycloadditions in this project. For example, consecutive inter- and intramolecular [2+2+2] cycloadditions of two o-phenylene-tethered triynes provided highly enantioselective synthesis of chiral substituted tetraphenylenes. The present protocol is a new and facile approach to the construction of chiral tetraphenylene skeleton. We also reported the enantioselective synthesis of the tripodal cage-type compounds with planar chirality. Intramolecular [2+2+2] cycloaddition of branched triynes, where diyne and alkyne moieties were connected by 2-aminophenol linkage, gave tripodal cyclophanes with almost perfect enantioselectivity.
|
