2009 Fiscal Year Final Research Report
New approach for the detection of cellular stresses based on chaperone-carbohydrate interactions
| Project/Area Number |
19350078
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Hokkaido University |
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Principal Investigator |
NIIKURA Kenichi Hokkaido University, 電子科学研究所, 准教授 (40360896)
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| Co-Investigator(Kenkyū-buntansha) |
IJIRO Kuniharu 北海道大学, 電子科学研究所, 教授 (90221762)
KOGURE Kentaro 京都薬科大学, 薬学部, 教授 (70262540)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 糖鎖 / 量子ドット / 核移行 / 細胞ストレス / シャペロン |
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| Research Abstract |
For quantitative detection of stress responses to cells, we have developed sugar-displaying CdTe as a stress sensing probe in cells. During three years (H19-H21), we obtained following two results;
1. GlcNAc-QDs were accumulated in cells when stimulating the cells by adding heavy metals as chemical stresses.
2. The coating of QDs with α-Glucose can efficiently promote the nuclear import of QDs. This fact leads to various medical applications, such as drug delivery systems (DDSs) and bioimaging.
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Research Products
(33 results)
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[Presentation] Preparation of fuctionalized virus-like particles enabling pH-mediated release of target molecules2010
Author(s)
Noriko Ohtake, Kenichi Niikura, Tadaki Suzuki, Shintaro Mikuni, Yasutaka Matsuo, Keita Nagakawa, Masataka Kinjo, Hirofumi Sawa, Kuniharu Ijiro
Organizer
International Symposium of Joint Research Network on Advanced Materials and Devices "彫" [Chou]
Place of Presentation
Hotel-Nidom, Hokkaido, Japan
Year and Date
20100325-20100326
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