2010 Fiscal Year Final Research Report
Studies on the Structure and Function of Phytochromes as Photoreceptive Chromoproteins Based on Synthetic Organic Chemistry
| Project/Area Number |
19350082
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kanazawa University |
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Principal Investigator |
INOMATA Katsuhiko Kanazawa University, 物質化学系, 教授 (50110599)
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| Project Period (FY) |
2007 – 2010
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| Keywords | フィトクロム / 光受容色素蛋白質 / 発色団 / 開環状テトラピロール / 全合成 / 構造と機能相関 / 光分子スイッチ |
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| Research Abstract |
Toward investigation of the structure and function of phytochromes as photoreceptive chromoproteins regulating photomorphogenesis in plants, we have developed an efficient and flexible method for the preparation of chromophores (PΦB, PCB, and BV) of phytochromes, and have found a lot of insights into phytochromes. For example, we could directly reveal the stereochemistry of the chromophore in red light absorbing Pr-form and far-red light absorbing Pfr-form of Agrobacterium phytochromes, Agp1 and Agp2, by the assembly experiments of the chemically synthesized locked chromophores with apophytochromes.
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