2009 Fiscal Year Final Research Report
Implementation of chemical biology using novel affinity resins
| Project/Area Number |
19350086
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tohoku University |
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Principal Investigator |
HOSOYA Ken Tohoku University, 大学院・環境科学研究科, 教授 (00209248)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBO Takuya 東北大学, 大学院・環境科学研究科, 助教 (20374994)
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| Project Period (FY) |
2007 – 2009
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| Keywords | アフィニティ担体 / ケミカルバイオロジー / 環境技術 / 生理活性 / タンパク質 |
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| Research Abstract |
I have developed completely new, monolithic affinity resins for researches of target proteins of certain bioactive substances, which have been very important for novel drag discovery. Based on careful studies, I have realized great suppression of non-specific adsorption of proteins based on "soft" surface of affinity resins and really improved capture of the target proteins, which have been never realized using commercially available affinity resins. In addition, using surface modification, environment of the immobilized ligand has been controlled to capture various target proteins in certain environment. These results will contribute implementation of chemical biology.
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