2009 Fiscal Year Final Research Report
Modeling of Transport Phenomena and Physical Stimulus Response in Engineered Cartilage Tissue Development
| Project/Area Number |
19360087
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fluid engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
WATANABE Masao Hokkaido University, 大学院・工学研究科, 准教授 (30274484)
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| Co-Investigator(Kenkyū-buntansha) |
SAWAE Yoshinori 九州大学, 大学院・工学研究院, 准教授 (10284530)
SAKAI Noburo 九州大学, 大学院・工学研究院, 助教 (60346814)
SANADA Toshiyuki 静岡大学, 工学部, 助教 (50403978)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 再生医療 / 軟骨細胞 / 輸送現象 / 拡散 / 移流 / 可視化 / モデリング |
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| Research Abstract |
We visualized transport phenomena in developing engineered cartilage tissues. The promotion of mass transfer due to the existence of cells inside test pieces are observed. The cell metabolism increased the diffusion transport. Generated polymers that consist extra-cellular matrices, such as negatively charged keratan sulfate, restrict diffusion transport. We also clarified the effects of advection transport due to the compression on diffusion transport.
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