2010 Fiscal Year Final Research Report
Fluid mechanical study on the roles of the endothelial surface glycocalyx
| Project/Area Number |
19360090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fluid engineering
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| Research Institution | Kansai University |
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Principal Investigator |
SUGIHARA-SEKI Masako Kansai University, システム理工学部, 教授 (80150225)
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| Co-Investigator(Kenkyū-buntansha) |
ITANO Tomoaki 関西大学, システム理工学部, 准教授 (30335187)
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| Co-Investigator(Renkei-kenkyūsha) |
AKINAGA Takeshi 関西大学, 先端科学技術推進機構, 非常勤研究員 (50512711)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 微小血管 / 糖鎖層 / 血球 / 物質輸送 / 数値シミュレーション / 電荷 |
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| Research Abstract |
The presence of fiber matrix layer of proteoglycans and glycoproteins at the surface of vascular endothelial cells has been reported and physiological roles of the layer have been investigated extensively. In the present study, we studied the transport of solute and solvent across the layer and the effect on blood cells, from fluid mechanical point of view. The present analysis has suggested that the layer plays an important role as a molecular filter and indicated significance effects of electric charge on the transport property.
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