2009 Fiscal Year Final Research Report
Feasibility of implantable liver tissues having a vascular-like blood flow network
| Project/Area Number |
19360371
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAKAI Yasuyuki The University of Tokyo, 生産技術研究所, 教授 (00235128)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 肝組織工学 / 胎児肝細胞 / 移植 / 三次元担体 / 液性因子 / 酸素供給 / 血流導入 |
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| Research Abstract |
Combination of 3D culture and soluble factors was very effective in maturation of fetal rat hepatocytes in vitro. Oxygen supply at appropriate exposure concentrations was also important to fully utilize the self-organization capacity of such hepatocyte progenitor population. Control of blood cell-to-implanted hepatocytes was shown to be a crucial issue in designing and engineering of implantable pre-vascularized liver tissues.
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