2009 Fiscal Year Final Research Report
Molecular simulation study of membrane morphology change induced by proteins
| Project/Area Number |
19370069
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKADA Shoji Kyoto University, 大学院・理学研究科, 准教授 (60304086)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ベシクル融合 / ベシクル発芽 / ラフト / 粗視化モデル / シミュレーション |
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| Research Abstract |
Membrane morphology change, such as cell fusion and cell division, is induced by related proteins. The aim of the research here is to develop a coarse-grained simulation model for protein-membrane complex and to apply it to the membrane morphology dynamics. We extended the multiple-basin model for proteins, used Noguchi model for lipids, and proposed the excluded volume and hydrophobic interaction terms for the protein-lipid interaction. By this new model, we successfully simulated vesicle formation, vesicle fusion, phase separation of 2-components vesicle, and budding addressing their mechanisms.
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Research Products
(30 results)
