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2008 Fiscal Year Final Research Report

Novel mechanisms underlying neural formation

Research Project

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Project/Area Number 19370092
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental biology
Research InstitutionThe University of Tokyo

Principal Investigator

TABATA Tetsuya  The University of Tokyo, 分子細胞生物学研究所, 教授 (10183865)

Co-Investigator(Kenkyū-buntansha) 佐藤 純  金沢大学, フロンティアサイエンス機構, 特任准教授 (30345235)
吉田 章子  東京大学, 分子細胞生物学研究所, 助教 (70372430)
Project Period (FY) 2007 – 2008
Keywords発生遺伝
Research Abstract

脳には様々な種類の多くの神経細胞がある。それらは神経前駆細胞から形成されるが、その数を調節するメカニズムは良く理解されていない。その理由の一つは前駆細胞の形成がランダムに起こるように見えるからであり規則性を見出すことに困難がある。ショウジョウバエの視覚を司る脳神経が規則正しく形成されることを発見した。本研究では、この系を用いて、神経前駆細胞が形成される機構の一端を明らかにした。

  • Research Products

    (17 results)

All 2010 2009 2008 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (16 results)

  • [Journal Article] Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT2008

    • Author(s)
      Yasugi, T., Umetsu, D., Murakami, S., Sato, M., Tabata, T.
    • Journal Title

      Development 135 (8)

      Pages: 1471-80

    • Peer Reviewed
  • [Presentation] Cellular and molecular mechanisms underlying neural formation in Drosophila visual system development2010

    • Author(s)
      Tetsuya Tabata
    • Organizer
      International Symposium on Drosophila Bio-Resource : Pioneering life science research with Drosophila Genetic Resources
    • Place of Presentation
      Kyoto
    • Year and Date
      20100317-20100318
  • [Presentation] EGFR and Notch Signaling Regulates the Progression of the Proneural Wave in the Drosophila Optic Lobe Development2009

    • Author(s)
      Tetsuo Yasugi, Umetsu Daiki, Tetsuya Tabata.
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      20091209-20091212
  • [Presentation] Spatio-temporal regulation of DER and Notch signaling pathways organizes the proneural wave progression in medulla neuroblast development. Neurobiology of Drosophila2009

    • Author(s)
      Tetsuya Tabata.
    • Organizer
      Cold Spring Harbor Laboratory
    • Place of Presentation
      Cold Spring Harbor, U.S.A.
    • Year and Date
      20090929-20091003
  • [Presentation] Role for the EGFR and JAK/STAT Signaling Pathway in the Drosophila Optic Lobe Development2009

    • Author(s)
      Tetsuo Yasugi, Umetsu Daiki, Satoshi Murakami, Makoto Sato, Tetsuva Tabata.
    • Organizer
      16th International Society of Developmental Biologists Congress 2009
    • Place of Presentation
      Edinburgh, Scotland, UK.
    • Year and Date
      20090906-20090910
  • [Presentation] EGFR and JAK/STAT Regulate Progression of Proneural Wave in the Drosophila Optic Lobe Development2009

    • Author(s)
      Tetsuo Yasugi, Daiki Umetsu, Satoshi Murakami, Makoto Sato, Tetsuya Tabata
    • Organizer
      CDB Symposium 2009 Shape and Porality
    • Place of Presentation
      Kobe.
    • Year and Date
      20090323-20090325
  • [Presentation] Cellular and molecular mechanisms underlying neural circuit formation in Drosophila visual system, GIST Workshop2008

    • Author(s)
      Tetsuya Tabata.
    • Organizer
      Gradients and Signalling : from chemotaxis to development
    • Place of Presentation
      Okinawa.
    • Year and Date
      20081117-20081121
  • [Presentation] Visual system development of Drosophila2008

    • Author(s)
      Tetsuya Tabata.
    • Organizer
      Frontiers in Developmental Biology
    • Place of Presentation
      Giens, France.
    • Year and Date
      20080913-20080917
  • [Presentation] Neuroblast Formation in the Optic Lobe Development Neurofly 20082008

    • Author(s)
      Tetsuo Yasugi, Daiki Umetsu, Satoshi Murakami, Makoto Sato, Tetsuya Tabata.
    • Organizer
      12th European Drosophila Neurobiology Confernce
    • Place of Presentation
      Wurzburg, Germany.
    • Year and Date
      20080906-20080910
  • [Presentation] The life of medulla neurons in the Drosophila visual center2008

    • Author(s)
      Tetsuya Tabata.
    • Organizer
      Gordon Research Conference, Visual system development
    • Place of Presentation
      New Port, U.S.A.
    • Year and Date
      20080810-20080815
  • [Presentation] Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT2008

    • Author(s)
      Tetsuo Yasugi, Daiki Umetsu, Satoshi Murakami, Makoto Sato, Tetsuya Tabata.
    • Organizer
      第41回日本発生生物学会
    • Place of Presentation
      徳島
    • Year and Date
      20080528-20080530
  • [Presentation] JAK/STAT signal regulates proneural wave progression in the optic lobe development2008

    • Author(s)
      Tetsuo Yasugi, Daiki Umetsu, Satoshi Murakami, Makoto Sato, Tetsuya Tabata.
    • Organizer
      49th Annual Drosophila Research Conference
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      20080402-20080406
  • [Presentation] JAK/STAT Signal Negatively Regulates Progression of Proneural Wave that Induces Neural Stem Cells2008

    • Author(s)
      Tetsuo Yasugi, Daiki Umetsu, Satoshi Murakami, Makoto Sato, Tetsuva Tabata.
    • Organizer
      CDB Symposium 2008 turning neurons into a nervous system
    • Place of Presentation
      Hyogo.
    • Year and Date
      20080324-20080326
  • [Presentation] Neurogenesis in the Drosophila visual center2008

    • Author(s)
      Tetsuya Tabata.
    • Organizer
      Progress in Developmental Biology, Swiss-Japanese seminar
    • Place of Presentation
      Arosa, Swiss.
    • Year and Date
      20080106-20080109
  • [Presentation] 神経幹細胞を形成する Proneural wave の進行はJAK/STATにより負に制御されている. シンポジウム 神経発生素過程の生体制御2007

    • Author(s)
      多羽田哲也, 八杉徹雄, 梅津大輝, 村上智史, 吉田章子, 佐藤純
    • Organizer
      第30回日本分子生物学会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      20071211-20071215
  • [Presentation] JAK/STAT Signal Regulates the Proneural Wave Progression in the Optic Lobe Development2007

    • Author(s)
      Tetsuo Yasugi, Daiki Umetsu, Satoshi Murakami, Shoko Yoshida, Makoto Sato, Tetsuya Tabata.
    • Organizer
      第8回日本シヨウジヨウバエ研究集会
    • Place of Presentation
      淡路
    • Year and Date
      20070701-20070702
  • [Presentation] Molecular mechanisms that underlie neuroblast formation in the optic lobe Visual Processing in insects : From Anatomy to Behavior2007

    • Author(s)
      Tetsuya Tabata.
    • Organizer
      2007 Janelia conference number 6
    • Place of Presentation
      HHMI Janelia Farm, Chevy Chase, U.S.A.
    • Year and Date
      20070429-20070502

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Published: 2011-06-18   Modified: 2016-04-21  

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