2009 Fiscal Year Final Research Report
Roles of membrane microdomains in fertilization and activation of development
| Project/Area Number |
19370094
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto Sangyo University |
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Principal Investigator |
SATO Ken-ichi Kyoto Sangyo University, 工学部, 教授 (30235337)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 受精 / シグナル伝達 / 細胞膜マイクロドメイン / Src / ウロプラキンIII |
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| Research Abstract |
On uroplakin III (UPIII), its mechanism for localization to the membrane microdomain and for negative regulation of Src. 2)Phosphorylation of hnRNP K and its physiological relevance to translational control of maternal mRNAs. 3) PI3-kinase and Akt as important components for fertilization signaling. 4)Molecular function of ARISX as a carbohydrate-containing protein. 5)Molecular mechanism of an enzymatic regulation of phospholipase Cζ, a sperm factor in mammals, that involves partial proteolysis. 6) Importance of tyrosine phosphorylation of Stat3 in human melanoma cell lines.
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Research Products
(15 results)
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[Journal Article] Expression, phosphorylation, and mRNA-binding of heterogeneous nuclear ribonucleo-protein K in Xenopus oocytes, eggs, and early embryos.2008
Author(s)
Iwasaki T, Koretomo Y, Fukuda T, Paronetto MP, Sette C, Fukami Y, Sato K.
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Journal Title
Dev Growth Differ 50
Pages: 23-40
Peer Reviewed
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