2009 Fiscal Year Final Research Report
Analysis of novel cell surface proteins affecting cell shape of bacteria
| Project/Area Number |
19380047
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Shinshu University |
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Principal Investigator |
SEKIGUCHI Junichi Shinshu University, 大学院・総合工学系研究科, 教授 (80111053)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hiroki 信州大学, 繊維学部, 准教授 (20262701)
HASHIMOTO Masayuki 信州大学, ファイバーナノテク国際若手研究者育成拠点, 助教 (80402139)
FUKUSHIMA Tatsuya 信州大学, ヒト環境科学研究支援センター, 助教 (20529200)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 微生物機能 / 表層蛋白質 / 細胞形態 / 細胞壁溶解酵素 / インヒビター |
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| Research Abstract |
Bacillus subtilis gene products (IseA and YqgA) associated with cell shape were investigated extensively. IseA is a proteinaceous inhibitor against the DL-endopeptidase family and its overexpression led to typical cell filamentation. It is likely that YqgA had some relation with cell wall lytic DL-endopeptidases (LytE, LytF and CwlS). The role of LytE, which is one of the synthetic lethal proteins, is investigated in detail. Moreover, enzymatic properties of B. subtilis CwlK and CwlT are reported.
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