2009 Fiscal Year Final Research Report
Molecular mechanism and bioprobes of cytokine receptor signaling
| Project/Area Number |
19380057
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KATAOKA Takao Kyoto Institute of Technology, 工芸科学研究科, 准教授 (20242307)
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| Project Period (FY) |
2007 – 2009
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| Keywords | シグナル伝達 / 生理活性 / 炎症性サイトカイン / NF-κB / ICAM-1 / オドロシドA / ペペロミン / ウアバイン |
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| Research Abstract |
Cytokines are soluble proteins secreted primarily by immunological cells and able to induce complex intracellular signaling pathways through binding to their specific receptors expressed on target cells. Pro-inflammatory cytokines regulate many biological processes such as inflammation, immunity, cell survival, and cell death, and thus involved in autoimmune diseases and carcinogenesis. In this study we identified small bioactive compounds (termed as bioprobes) that prevent signal transduction and gene expression in response to pro-inflammatory cytokines and further elucidated their mechanisms of actions.
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