2008 Fiscal Year Final Research Report
A reaction mechanism elucidation study based on many sugar-endo Type glycosidase complex analysi
| Project/Area Number |
19380064
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
HASHIMOTO Masaru Hirosaki University, 農学生命科学部, 教授 (40212138)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAIRI Kazuo 弘前大学, 農学生命科学部, 教授 (10003526)
SAITO Minoru 弘前大学, 理工学研究科, 教授 (60196011)
KIDOKORO Syunichi 長岡技術科学大学, 工学部, 准教授 (80195320)
SHIMIZU Hiroki 独立法人産業技術総合研究所, 創薬シーズ探索ラボ, 研究員 (30344716)
SHIMIZU Tetsuya 独立法人理化学研究所, 研究技術開発室 (80435651)
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| Project Period (FY) |
2007 – 2008
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| Keywords | endo型グリコシダーゼ / 反応機構 / 基質ミミック / 複合体形成 |
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| Research Abstract |
本研究課題では、endo型グリコシダーゼの反応の詳細を解明する目的で、アナログを分子動力学手法を用い設計したいくつかの基質を合成し、それらと対象酵素との複合体形成について熱化学分析により測定、また、共結晶化などを試みた。
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Research Products
(52 results)
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[Journal Article] Isolation and absolute stereochemistry of optically active sydonic acid from from Glonium sp. (Hysteriales, Ascomycota)2009
Author(s)
Kudo, S., Murakami, T., MiyanisTanaka, K., Takada, N., Hashimoto, M.
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Journal Title
Biosci. Biotech. Biochem 73
Pages: 203-204
Peer Reviewed
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[Journal Article] Syntheses of Lambertellols and Their Stable Analogues ; Investigation of the Real Active Species in the Mycoparasitism by Lambertella Speciese Analogues ; Investigation of the Real Active Species in the Mycoparasitism by Lambertella Speciese2008
Author(s)
Nomiya, M., Murakami, T., Takada, N., Okuno, T., Harada, Y., Hashimoto, M
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Journal Title
J. Org. Chem 73
Pages: 5039-5047
Peer Reviewed
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[Journal Article] Synthesis of D-trigalacturonic acid methylglycoside2008
Author(s)
Yamamoto, K., Sato, Y., Ishimori, A., Miyairi, K., Okuno, T., Nemoto, N.,Shimizu, H., Kidokoro, S., Hashimoto, M.
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Journal Title
Biosci. Biotech. Biochem 71
Pages: 1230-1235
Peer Reviewed
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