2009 Fiscal Year Final Research Report
Development of anti-obese dietary peptides which functions via gut hormone secretion
| Project/Area Number |
19380071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Hokkaido University |
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Principal Investigator |
HARA Hiroshi Hokkaido University, 大学院・農学研究院, 教授 (70198894)
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| Co-Investigator(Kenkyū-buntansha) |
HIRA Tohru 北海道大学, 大学院・農学研究院, 助教 (10396301)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 消化管ホルモン / 血糖値 / Glucagon-like peptide-1 / コレシストキニン / 食品ペプチド |
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| Research Abstract |
From various dietary peptides, we found that country bean peptide and beer yeast peptide have potent activity to stimulate a satiating gut hormone CCK in enteroeondcrine cell line. Oral preload of beer yeast peptide reduced following food consumption in rats. We also found that a hydrolysate prepared from corn protein Zein stimulates another gut hormone GLP-1. Ileal administration of Zein hydrolysate strongly induced GLP-1 secretion and subsequent insulin secretion in awake rats, which results in the improvement of glucose tolerance. These findings have revealed that dietary peptides are promising factor for prevention of overeating and hyperglycemia via stimulating gut hormone secretions.
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Research Products
(19 results)
