2009 Fiscal Year Final Research Report
Relationship between metabolic conversion of dietary flavonoids and their functions on oxidative stress
| Project/Area Number |
19380075
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TERAO Junji The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (60093275)
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| Co-Investigator(Kenkyū-buntansha) |
MUROTA Kaeko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40294681)
KAWAI Yoshichika 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50380027)
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| Project Period (FY) |
2007 – 2009
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| Keywords | フラボノイド / 酸化ストレス / ケルセチン / 血管内皮細胞 / 動脈硬化 / 神経細胞 / パーキンソン病 / セロトニン |
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| Research Abstract |
This study was aimed to clarify the relationship between metabolic conversion of dietary flavonoids and their functions on oxidative stress control using quercetin, an antioxidative flavonoid ubiquitously present in fruits nad vegetables. The results indicate that conjugated quercetin metabolites exert a powerful antioxidant activity after deconjugation via activated macrophage-like cells. It is likely that dietary flavonoids are helpful in the suppression of oxidatives stress occurring in the target sites of intima and CNS by converting to their aglyone under stress-loaded state.
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[Journal Article] Flavonoids as substrates and inhibitors of myeloperoxidase:molecular actions of aglycons and metabolites.2008
Author(s)
Shiba Y, Kinoshita T, Chuman H, Taketani Y, Takeda F, Kate Y, Naito M, Kawabata K, Ishisaka A, Terao J, Kawai Y.
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Journal Title
Chem Res. Toxicol 21
Pages: 1600-1609
Peer Reviewed
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