2009 Fiscal Year Final Research Report
Molecular control mechanism of left-right asymmetry of flounders
| Project/Area Number |
19380108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General fisheries
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Tohru Tohoku University, 大学院・農学研究科, 教授 (70344330)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Hisashi 名古屋大学, 生物機能開発研究センター, 助教 (30359757)
UJI Susumu 独立行政法人水産総合研究センター, 養殖研究所, 研究員 (40372049)
ARITAKI Masato 独立行政法人水産総合研究センター, 宮古栽培漁業部, 場長 (00426298)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 異体類 / ヒラメ / 左右非対称性 / Nodal経路 / pitx2 / 脳 / 変態 / 色素前駆細胞 |
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| Research Abstract |
Flounder larvae transform from symmetric to asymmetry shape by moving one eye at metamorphosis. Final shape is divided to sinistral species (e.g. Paralichthys olivaceus) and dextral species (e.g. Varasper veriegatus). We have elucidated the developmental control system of eye-sidedness of flounders. Eye migration proceeds in coordination with dynamic asymmetric formation of forebrain and cranium. Final L-R determinant gene, pitx2, of the Nodal pathway, known to control the laterality of internal organs, is expressed in the left side of dorsal diencephalon in flounders to lateralize the eye-sidedness. When pitx2 expression is suppressed, which eye migrates is randomized, resulting in reversal of eye-sidedness in part of larvae. The mechanism that divides flounders to sinistral and dextral species has close relation with the fact that the laterality of the optic chiasma is fixed in opposite direction between two species.
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