Relationship between photic environment and neuropeptides in fish

2009 Fiscal Year Final Research Report

• Project/Area Number: 19380115
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General fisheries
• Research Institution: Kitasato University
• Principal Investigator: TAKAHASHI Akiyoshi Kitasato University, 海洋生命科学部, 教授 (10183849)
• Co-Investigator(Kenkyū-buntansha): AMANO Masafumi 北里大学, 海洋生命科学部, 教授 (10296428) ; MATSUDA Kohei 富山大学, 大学院・理工学研究科, 教授 (60222303) ; MORIYAMA Shunsuke 北里大学, 海洋生命科学部, 教授 (50222352)
• Project Period (FY): 2007 – 2009
• Keywords: マツカワ / キンギョ / 黒色素胞刺激ホルモン / メラニン凝集ホルモン / 特定波長光 / 発光ダイオード / 黒色素胞刺激ホルモン受容体 / メラニン凝集ホルモン受容体

Research Abstract

The growth of flounders was faster under green-light illumination and slower under red-light illumination than that of fish reared under environmental light conditions. Thus, these results suggest that green light stimulates growth, whereas red light inhibits growth of the fish. Melanin-concentrating hormone and melanocyte- stimulating hormone are neuropeptides of the hypothalamo-pituitary axis. Further, these neuropeptides are associated with regulation of food intake. Molecular cloning of the receptors for these neuropeptides was performed in order to accumulate molecular tools for investigating the relationships between photic environment and fish physiology.

Research Products

• [Journal Article] Differential expressions of melanocortin receptor subtypes in melanophores and xanthophores of barfin flounder. (2010)
  • Author(s): Kobayashi, Y., Tuchiya, K., Yamanome, T., Schioth, H.B., Takahashi, A.
  • Journal Title: Gen. Comp. Endocrinol (in press)
• [Journal Article] 光環境と魚類生理～マツカワの無眼側黒化から成長促進へ (2009)
  • Author(s): 山野目健、高橋明義
  • Journal Title: 比較内分泌学 35 Pages: 93-98
• [Journal Article] Regulation of food intake by melanin-concentrating hormone in goldfish. (2009)
  • Author(s): Matsuda, K., Kojima, K., Shimakura, S., Takahashi, A.
  • Journal Title: Peptides 30 Pages: 2060-2065
• [Journal Article] Molecular cloning and expression of the two melanin-concentrating hormone receptors in goldfish. (2009)
  • Author(s): Mizusawa, K., Saito, Y., Wang, Z., Kobayashi, Y., Matsuda, K., Takahashi, A.
  • Journal Title: Peptides 30 Pages: 1990-1996
• [Journal Article] Melanin-concentrating hormone: A neuropeptide hormone affecting the relationship between photic environment and fish with special reference to background color and food intake regulation. (2009)
  • Author(s): Amano, M., Takahashi, A.
  • Journal Title: Peptides 30 Pages: 1979-1984
• [Journal Article] Structural and functional diversity of proopiomelanocortin in fish with special reference to barfin flounder. (2009)
  • Author(s): Takahashi, A., Kobayashi, Y., Amano, M., Yamanome, T.
  • Journal Title: Peptides 30 Pages: 1374-1382
• [Journal Article] Possible paracrine function ofα-melanocyte-stimulating hormone and inhibition of its melanin-dispersing activity by N-terminal acetylation in the skin of the barfin flounder, Verasper moseri. (2009)
  • Author(s): Kobayashi, Y., Mizusawa, K., Yamanome, T., Chiba, H., Takahashi, A.
  • Journal Title: Gen. Comp. Endocrinol 161 Pages: 419-424
• [Journal Article] White background stimulates the food intake of a pleuronectiform fish the barfin flounder, Verasper moseri (Jordan et Gilbert). (2009)
  • Author(s): Sunuma, T., Yamanome, T., Amano, M., Takahashi, A., Yamamori, K.
  • Journal Title: Aquaculture Res 40 Pages: 748-751
• [Journal Article] Relationship between melanin-concentrating hormone-and neuropeptide Y-containing neurons in the goldfish hypothalamus. (2009)
  • Author(s): Matsuda, M., Kojima, K., Shimakura, S., Miura, T., Uchiyama, M., Shioda, S., Ando, H., Takahashi, A.
  • Journal Title: Comp. Biochem. Physiol. A 153 Pages: 3-7
• [Journal Article] Green light stimulates somatic growth in the barfin flounder Verasper moseri. (2009)
  • Author(s): Yamanome, T., Mizusawa, K., Hasegawa, E., Takahashi, A.
  • Journal Title: J. Exp. Zool 311A Pages: 73-79
• [Journal Article] Transcription elements and functional expression of proopiomelanocortin genes in the pituitary gland of the barfin flounder. (2008)
  • Author(s): Kobayashi, Y., Chiba, H., Amiya, N., Yamanome, T., Mizusawa, K., Amano, M., Takahashi, A.
  • Journal Title: Gen. Comp. Endocrinol 158 Pages: 259-267
• [Journal Article] Neuronal interaction between melanin-concentrating hormone-andα-melanocyte-stimulating hormone-containing neurons in the goldfish hypothalamus. (2008)
  • Author(s): Shimakura, S., Kojima, K., Nakamachi, T., Kageyama, H., Uchiyama, M., Shioda, S., Takahashi, A., Matsuda, K.
  • Journal Title: Peptides 29 Pages: 1432-1440
• [Journal Article] Interaction of orexin/hypocretin-like immunoreactive neurons with melanin-concentrating hormone andα-melanocyte-stimulating hormone neurons in the brain of a pleuronectiform fish, barfin flounder. (2008)
  • Author(s): Amiya, N., Amano, M., Iigo, M., Yamanome, T., Takahashi, A., Yamamori, K.
  • Journal Title: Fish Sci 74 Pages: 1040-1046
• [Journal Article] Evaluation of posttranslational processing of proopiomelanocortin in the banded houndshark pituitary by combined cDNA cloning and mass spectrometry. (2008)
  • Author(s): Takahashi, A., Kobayashi, Y., Moriyama, S., Hyodo, S.
  • Journal Title: Gen. Comp. Endocrinol 157 Pages: 41-48
• [Journal Article] α-Melanocyte-stimulating hormone mediates melanin-concentrating hormone-induced anorexigenic action in goldfish. (2008)
  • Author(s): Shimakura, S., Miura, T Maruyama, K., Nakamachi, T., Uchiyama, M., Kageyama, H., Shioda, S., Takahashi, A., Matsuda, K.
  • Journal Title: Hormones and Behavior 53 Pages: 323-328
• [Journal Article] Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on prolactin and somatolactin release from the goldfish pituitary in vitro. (2008)
  • Author(s): Matsuda, K., Nejigaki, Y., Satoh, M., Shimaura, C., Tanaka, M., Kawamoto, K., Uchiyama, M., Kawauchi, H., Shioda, S., Takahashi, A.
  • Journal Title: Regul. Pept 145 Pages: 72-79
• [Journal Article] Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder, Verasper moseri. (2008)
  • Author(s): Kobayashi, Y., Tsuchiya, K., Yamanome, T., Schioth, H.B., Kawauchi, H., Takahashi, A.
  • Journal Title: Gen. Comp. Endocrinol 155 Pages: 280-287
• [Journal Article] Effects of background color on GnRH and MCH levels in the barfin flounder brain. (2008)
  • Author(s): Amiya, N., Amano, M., Yamanome, T., Yamamori, K., Takahashi, A.
  • Journal Title: Gen. Comp. Endocrinol 155 Pages: 88-93
• [Journal Article] Melanocyte-stimulating hormone facilitates hypermelanosis on the non-eyed side of the barfin flounder, a pleuronectiform fish. (2007)
  • Author(s): Yamanome, T., Chiba, H., Takahashi, A.
  • Journal Title: Aquaculture 270 Pages: 505-511
• [Journal Article] RFamide peptides inhibit the expression of melanotropin and growth hormone genes in the pituitary of an agnathan, the sea lamprey, Petromyzon marinus. (2007)
  • Author(s): Moriyama, M., Kasahara, M., Amiya, N., Takahashi, A., Amano, A., Sower, S.A., Yamamori, K., Kawauchi, H.
  • Journal Title: Endocrinology 148 Pages: 3740-3749
• [Journal Article] cDNA cloning of proopiomelanocortin (POMC) and mass spectrometric identification of POMC-derived peptides from snake and alligator pituitaries. (2007)
  • Author(s): Kobayashi, Y., Sakamoto, T., Iguchi, K., Imai, Y., Hoshino, M., Lance, V.A., Kawauchi, H., Takahashi, A.
  • Journal Title: Gen. Comp. Endocrinol 152 Pages: 73-81
• [Journal Article] Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes. (2007)
  • Author(s): Haitina, T., Klovins, J., Takahashi, A., Lowgren, M, Ringholm, A., Enberg, J., Kawauchi, H., Larson, E.T., Fredriksson, R., Schioth, H.B.
  • Journal Title: BMC Evol Biol 7 Pages: 101-114
• [Journal Article] Feeding-induced changes of melanin-concentrating hormone (MCH)-like immunoreactivity in the goldfish brain. (2007)
  • Author(s): Matsuda, K., Shimakura, S., Miura, T., Maruyama, K., Uchiyama, M., Kawauchi, H., Shioda, S., Takahashi, A.
  • Journal Title: Cell Tissue Res 328 Pages: 375-382
• [Journal Article] Further evidence for ancient role of ACTH peptides at melanocortin (MC) receptors; pharmacology of dogfish and lamprey peptides at dogfish MC receptors. (2007)
  • Author(s): Haitina, T., Takahashi, A., Holmen, L., Enberg, J., Schioth, H.B.
  • Journal Title: Peptides 28 Pages: 798-805
• [Journal Article] Hypermelanosis on the blind side of Japanese flounder Paralichthys olivaceus is diminished by rearing in white tank. (2007)
  • Author(s): Yamanome, T., Amano, M., Amiya, N., Takahashi, A.
  • Journal Title: Fish. Sci 73 Pages: 466-468
• [Journal Article] The melanin-concentrating hormone receptor 2 (MCH-R2) mediates the effect of MCH to control body color for background adaptation in the barfin flounder. (2007)
  • Author(s): Takahashi, A., Kosugi, T., Kobayashi, Y., Yamanome, Y., Schioth, H.B., Kawauchi, H.
  • Journal Title: Gen. Comp. Endocrinol 151 Pages: 210-219
• [Journal Article] Profiles ofα-melanocyte-stimulating hormone in the Japanese flounder as revealed by a newly developed time-resolved fluoroimmunoassay and immunohistochemistry. (2007)
  • Author(s): Amiya, N., Amano, M., Takahashi, A., Yamanome, T., Yamamori, K.
  • Journal Title: Gen. Comp. Endocrinol 151 Pages: 135-141
• [Journal Article] Immunohistochemical localization of orexin/hypocretin-like immunoreactive peptides and melanin-concentrating hormone in the brain and pituitary of medaka. (2007)
  • Author(s): Amiya, N., Amano M., Oka, Y., Iigo, M., Takahashi, A., Yamamori, K.
  • Journal Title: Neurosci. Let 427 Pages: 16-21
• [Presentation] Characterization of two melanin-concentrating hormone receptor subtypes in goldfish (2009)
  • Author(s): Mizusawa, K., Saito, Y., Wang, Z., Kobayashi, Y., Matsuda, K., Takahashi, A.
  • Organizer: 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2009-06-23
• [Presentation] Identification of cells expressing proopiomelanocortin and its receptors in the skin of barfin flounder (2009)
  • Author(s): Kobayashi, Y., Yamanome, T., Takahashi, A.
  • Organizer: 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2009-06-23
• [Presentation] Molecular cloning of a receptor for melanocyte-stimulating hormone in masu salmon (2008)
  • Author(s): Kobayashi, Y., Amiya, N., Yamanome, T., Amano, M., Takahashi, A.
  • Organizer: 5th World Fisheries Congress
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20081023-20081024
• [Presentation] Expression of the proopiomelanocortin genes in the pituitary gland of barfin flounder does not always correlated to background color (2008)
  • Author(s): Kobayashi, Y., Mizusawa, K., Amiya, N., Yamanome, T., Amano, M., Takahashi, A.
  • Organizer: 24th Conference of European Comparative Endocrinologists
  • Place of Presentation: Genoa, Italy
  • Year and Date: 2008-09-03
• [Presentation] Structural and functional diversity of proopiomelanocortin in fish with special reference to the barfin flounder. First Meeting of the Japan Branch of the International Neuropeptide Society (2008)
  • Author(s): Takahashi, A., Kobayashi, Y.
  • Organizer: International Symposium on Biological Active Peptides: Peptide Diversity
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2008-08-31
• [Presentation] Evaluation of posttranslational processing of proopiomelanocortin in the banded houndshark pituitary by combined cDNA cloning and mass spectrometry (2008)
  • Author(s): Takahashi, A., Kobayashi, Y., Moriyama, M., Hyodo, S.
  • Organizer: Sixth International Symposium on Fish Endocrinology
  • Place of Presentation: Calgary, Canada
  • Year and Date: 2008-06-25
• [Book] 下垂体ホルモンの多様性内分泌と生命現象シリーズ21世紀の動物科学10(長濱嘉孝、井口泰泉編) (2007)
  • Author(s): 川内浩司、高橋明義、森山俊介
  • Total Pages: 7-39
  • Publisher: 培風館
• [Book] 鎮痛ペプチドホルモンハンドブック新訂eBook版(日本比較内分泌学会編) (2007)
  • Author(s): 高橋明義
  • Total Pages: 346-407
  • Publisher: 南山堂
• [Book] プロオピオメラノコルチン由来のホルモンホルモンハンドブック新訂eBook版(日本比較内分泌学会編) (2007)
  • Author(s): 高橋明義
  • Total Pages: 697-775
  • Publisher: 南山堂